Positive emotion-specific changes in the gene expression profile of tickled rats
Positive emotion-specific changes in the gene expression profile of tickled rats
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DOI：
10.3892/mmr_00000077
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发表时间：
2009-03-01
影响因子：
3.4
通讯作者：
Murakami, Kazuo
中科院分区：
文献类型：
--
作者：
Hori, Miyo;Hayashi, Takashi;Murakami, Kazuo
本研究的目的是研究青少年大鼠大脑中伴随积极情绪的触觉刺激（挠痒痒）后基因表达的变化。我们观察到一个积极的情绪反应（50 kHz的超声波发声）挠痒痒后，使用修改版本的Panksepp方法，然后全面比较基因表达水平在下丘脑的挠痒痒的大鼠和对照组大鼠使用微阵列技术。刺激4周后，41，012个基因（包括转录本）中有321个基因的表达水平发生了变化; 136个基因表达上调（>1.5倍），185个基因表达下调（>1.5倍）。
The aim of this study was to investigate changes in gene expression after tactile stimulation (tickling) accompanied by positive emotion in the adolescent rat brain. We observed a positive emotional response (50-kHz ultrasonic vocalizations) after tickling using a modified version of the Panksepp method, and then comprehensively compared gene expression levels in the hypothalamus of the tickled rats and control rats using the microarray technique. After 4 weeks of stimulation, the expression levels of 321 of the 41,012 genes (including transcripts) were changed; 136 genes were up-regulated (>1.5-fold) and 185 were down-regulated (