Cord Blood Bisphenol A Levels and Reproductive and Thyroid Hormone Levels of Neonates: The Hokkaido Study on Environment and Children’s Health
Cord Blood Bisphenol A Levels and Reproductive and Thyroid Hormone Levels of Neonates: The Hokkaido Study on Environment and Children’s Health
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DOI：
10.1097/ede.0000000000000716
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发表时间：
2017-10
期刊：
影响因子：
5.4
通讯作者：
Machiko Minatoya;S. Sasaki;A. Araki;C. Miyashita;Sachiko Itoh;J. Yamamoto;T. Matsumura;T. Mitsui;K. Moriya;Kazutoshi Cho;Keita Morioka;H. Minakami;N. Shinohara;R. Kishi
中科院分区：
文献类型：
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作者：
Machiko Minatoya;S. Sasaki;A. Araki;C. Miyashita;Sachiko Itoh;J. Yamamoto;T. Matsumura;T. Mitsui;K. Moriya;Kazutoshi Cho;Keita Morioka;H. Minakami;N. Shinohara;R. Kishi
背景：双酚A（BPA）被广泛使用，BPA暴露在发达国家几乎无处不在。虽然动物研究表明产前BPA暴露对健康的不良影响，包括生殖功能障碍和甲状腺功能破坏，可能以性别特异性的方式，流行病学研究的结果还不足以证明这些不良影响。鉴于对人类的研究非常有限，本研究的目的是调查脐带血BPA水平与新生儿生殖和甲状腺激素水平之间的关联，以及新生儿性别之间的关联是否存在差异。方法：研究人群包括2002年至2005年在日本札幌一家医院招募的514名北海道研究参与者。采用ID-LC/MS/MS法测定脐血中BPA含量，定量限为0.040 ng/ml。我们测量了脐带血中九种生殖激素水平，甲状腺激素水平从新生儿筛查试验数据中获得。有283名受试者，他们都有BPA和激素水平的测量，包括最终分析。结果：脐血BPA几何均值为0.051ng/ml。调整后，BPA水平与催乳素（PRL）呈负相关（=-0.38）。婴儿性别和BPA水平对PRL的影响存在相互作用;在男孩中发现弱负相关（=-0.12），而在女孩中发现弱正相关（= 0.14）。BPA水平与男性睾酮、雌二醇和孕酮水平呈弱正相关。BPA和甲状腺激素水平之间没有关联。结论：我们的研究结果表明，胎儿双酚A水平可能与某些生殖激素水平的新生儿在性别特异性的方式变化，但进一步的调查是必要的。
Background: Bisphenol A (BPA) is widely used and BPA exposure is nearly ubiquitous in developed countries. While animal studies have indicated adverse health effects of prenatal BPA exposure including reproductive dysfunction and thyroid function disruption possibly in a sex-specific manner, findings from epidemiologic studies have not been enough to prove these adverse effects. Given very limited research on human, the aim of this study was to investigate associations between cord blood BPA levels and reproductive and thyroid hormone levels of neonates and whether associations differed by neonate sex. Methods: The study population included 514 participants of the Hokkaido study recruited from 2002 to 2005 at one hospital in Sapporo, Japan. The BPA level in cord blood was determined by ID-LC/MS/MS, and the limit of quantification was 0.040 ng/ml. We measured nine types of reproductive hormone levels in cord blood, and thyroid hormone levels were obtained from neonate mass screening test data. There were 283 subjects, who had both BPA and hormone levels measurements, included for the final analyses. Results: The geometric mean of cord blood BPA was 0.051 ng/ml. After adjustment, BPA level was negatively associated with prolactin (PRL) ( = −0.38). There was an interaction between infant sex and BPA levels on PRL; a weak negative association was found in boys ( = −0.12), whereas a weak positive association was found in girls ( = 0.14). BPA level showed weak positive association with testosterone, estradiol, and progesterone levels in boys. No association was found between BPA and thyroid hormone levels. Conclusions: Our findings suggested that fetal BPA levels might be associated with changes in certain reproductive hormone levels of neonates in a sex-specific manner, though further investigations are necessary.