Age at menarche, menstrual characteristics, and risk of preeclampsia.
Age at menarche, menstrual characteristics, and risk of preeclampsia.
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DOI：
10.5402/2011/472083
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Williams MA
中科院分区：
文献类型：
--
作者：
Abetew DF;Enquobahrie DA;Dishi M;Rudra CB;Miller RS;Williams MA
我们在一项妊娠队列研究的参与者（n = 3，365）中检查了月经初潮年龄和月经特征与先兆子痫风险的关系。通过面对面访谈和病历摘要收集数据。采用Logistic回归估计校正后的比值比（OR）和95%置信区间（95%CI）。月经初潮年龄与先兆子痫风险呈显著负相关（趋势P值< 0.05）。只有孕前体重指数<25 kg/m2的妇女才有较长的月经周期（>36天）与先兆子痫的高风险相关（交互作用P值= 0.04）。月经初潮早与先兆子痫的高风险相关。孕前体重可能改变月经周期长与先兆子痫风险的关系。
We examined associations of age at menarche and menstrual characteristics with the risk of preeclampsia among participants (n = 3,365) of a pregnancy cohort study. Data were collected using in-person interviews and medical record abstraction. Logistic regression was used to estimate adjusted odds ratio (OR) and 95% confidence interval (95% CI). There was a significant inverse association between age at menarche and risk of preeclampsia (P value for trend < 0.05). Association of long cycle length (>36 days) with higher risk of preeclampsia was present only among women who had prepregnancy body mass index <25 kg/m2 (interaction P value = 0.04). Early menarche is associated with higher risk of preeclampsia. Prepregnancy weight may modify associations of long menstrual cycles with risk of preeclampsia.