Randomized trial assessing gastric emptying in patients with chronic hepatitis C during interferon-alpha or -beta therapy and effect of cisapride.
Randomized trial assessing gastric emptying in patients with chronic hepatitis C during interferon-alpha or -beta therapy and effect of cisapride.
复制标题
评估慢性丙型肝炎患者在干扰素-α或-β治疗期间胃排空以及西沙比利效果的随机试验。
DOI：
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发表时间：
2002
影响因子：
3.1
通讯作者：
H. Ochi
中科院分区：
文献类型：
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作者：
S. Nishiguchi;S. Shiomi;Hiroko Kurooka;Y. Iwata;N. Sasaki;A. Tamori;D. Habu;T. Takeda;J. Kawabe;H. Ochi
我们研究了α干扰素或β干扰素治疗对胃排空和消化道症状的影响。西沙必利对胃排空和消化道症状的影响也进行了评价。研究对象为48例慢性丙型肝炎患者。所有患者随机分为4组（A，干扰素-α组; B，干扰素-α和西沙必利组; C，干扰素-β组; D，干扰素-β和西沙必利组）。在干扰素治疗开始前和治疗开始后两周测量胃排空。计算胃排空半衰期（T1/2）。通过将干扰素治疗后的T1/2除以干扰素治疗前的T1/2来计算T1/2比值。在胃排空试验时测定消化症状评分。A、C组干扰素治疗后T1/2均高于治疗前（P分别为0.002和0.059）。A组和C组治疗后消化道症状评分均高于治疗前（P分别为0.012和0.093）。B组T1/2比值明显低于A组（P = 0.021），D组T1/2比值低于C组，但差异无统计学意义（P = 0.057）。与干扰素β相比，干扰素α与胃排空更大的延迟和更高的症状评分相关。西沙必利可纠正胃排空延迟并缓解相关消化道症状。
We examined the effects of interferon-alpha or -beta therapy on gastric emptying and digestive symptoms. The effects of cisapride on gastric emptying and digestive symptoms were also evaluated. The subjects were 48 patients with chronic hepatitis C. All patients were randomly assigned to one of four groups (A, interferon-alpha group; B, interferon-alpha and cisapride group; C, interferon-beta group; D, interferon-beta and cisapride group). Gastric emptying was measured before initiation of interferon therapy and two weeks after initiation of therapy. The half-time of gastric emptying (T1/2) was calculated. The T1/2 ratio was calculated by dividing the T1/2 after interferon therapy by the T1/2 before interferon therapy. Digestive symptom scores were determined at the time of the gastric emptying tests. The T1/2 after interferon therapy was higher than that before therapy in groups A and C (P = 0.002 and 0.059, respectively). The digestive symptom score after interferon therapy was higher than that before therapy in groups A and C (P = 0.012 and 0.093, respectively). The T1/2 ratio in group B was significantly lower than that in group A (P = 0.021), and the T1/2 ratio in group D was lower than that in group C, but the difference did not reach statistical significance (P = 0.057). Interferon-alpha is associated with a greater delay in gastric emptying and a higher symptom score than is interferon-beta. Administration of cisapride corrects the delayed gastric emptying and relieves associated digestive symptoms.