Restoring neuron connections.
Restoring neuron connections.
复制标题
恢复神经元连接。
DOI：
10.1126/science.abd4762
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Salinas PC
中科院分区：
文献类型：
--
作者：
Salinas PC
突触的结构和功能完整性对于神经元回路功能以及动物响应和适应环境的能力至关重要。然而，突触在发育和神经退行性疾病中以及在脑和脊髓损伤（SCI）后变得功能障碍或丢失。突触完整性的缺陷会导致认知障碍和运动障碍。为了恢复SCI后受损的神经元回路，针对抑制轴突生长的Nogo等分子的抗体疗法正在进行临床试验（1）。对于其他疾病，如阿尔茨海默病（AD），正在测试阻断致病分子淀粉样蛋白-β或其下游效应作为潜在的治疗方法（2）。为了开发有效的方法来恢复受损的突触，应该仔细考虑突触发生因子的多样性。为了克服这一点，在第1074页的这个问题，铃木等人。(3)报道了一种结构引导的合成肽，以恢复小鼠中受损和受损回路的突触完整性。
The structural and functional integrity of synapses is crucial for neuronal circuit function and for the ability of animals to respond and adapt to their environment. However, synapses become dysfunctional or are lost in developmental and neurodegenerative disorders, and after brain and spinal cord injury (SCI). Deficiency in synapse integrity contributes to cognitive impairment and motor disability. To restore damaged neuronal circuits after SCI, antibody therapy against molecules such as Nogo, which inhibits axon growth, are in clinical trials (1). For other conditions such as Alzheimer's disease (AD), blockade of the pathogenic molecule amyloid-β or its downstream effects are being tested as potential therapies (2). To develop effective approaches for restoring impaired synapses, careful consideration should be given to the diversity of synaptogenic factors. To overcome this, on page 1074 of this issue, Suzukiet al.(3) report a structurally guided synthetic peptide to restore synaptic integrity of damaged and impaired circuits in mice.