Assessment of reference ranges for blood Cu, Mn, Se and Zn in a selected Italian population
Assessment of reference ranges for blood Cu, Mn, Se and Zn in a selected Italian population
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DOI：
10.1016/j.jtemb.2010.12.004
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发表时间：
2011-01-01
影响因子：
3.5
通讯作者：
Forte, Giovanni
中科院分区：
文献类型：
--
作者：
Bocca, Beatrice;Madeddu, Roberto;Forte, Giovanni
对生活在努奥罗省（意大利岛屿撒丁岛）的 215 名非职业暴露成人受试者的血液铜、锰、硒和锌参考范围进行了评估。对血液进行微波辅助酸消解后，通过扇形场电感耦合等离子体质谱法测定金属。以 P5-P95 百分位（几何平均值，GM）估计的血液参考范围铜为 776-1495 μg/L (1036 μg/L)；锰4.73-17.0微克/升（8.91微克/升）； Se 为 106-185 μg/L (140 μg/L)，Zn 为 4686-8585 μg/L (6418 μg/L)。然后将这些结果按性别、年龄、饮酒量、吸烟习惯和居住区域进行分层。雌性Cu的GM值(1127μg/L)显着高于雄性(957μg/L)。年龄、饮酒量、吸烟习惯和居住地区对血铜没有影响。相对于男性（8.01μg/L）和饮酒者（9.67μg/L）相比，女性（9.98μg/L）的Mn GM显着高于不饮酒者（8.38μg/L）。其他变量没有改变 Mn 数据。硒浓度随个体因素的变化没有显着差异。就锌而言，男性的GM为6804μg/L，女性为6031μg/L，饮酒者的血锌含量（6618μg/L）高于戒酒者（6155μg/L）。此外，血锌不受年龄、吸烟习惯和居住地的影响。 (C) 2010 爱思唯尔有限公司。版权所有。
The reference ranges for blood Cu, Mn, Se and Zn of 215 adult subjects non-occupationally exposed and living in the Nuoro province (Sardinia, insular Italy) were assessed. Metals were determined by sector field inductively coupled plasma mass spectrometry after microwave-assisted acid digestion of blood. The blood reference ranges estimated as P5-P95 percentiles (geometric mean, GM) were 776-1495 mu g/L (1036 mu g/L) for Cu; 4.73-17.0 mu g/L (8.91 mu g/L) for Mn; 106-185 mu g/L (140 mu g/L) for Se and 4686-8585 mu g/L (6418 mu g/L) for Zn. These results were then stratified for sex, age, alcohol consumption, smoking habit and living area. The GM value of Cu was significantly higher in females (1127 mu g/L) than in males (957 mu g/L). Age, alcohol intake, smoking habit and residential area did not influence blood Cu. The GM of Mn was significantly higher in females (9.98 mu g/L) respect to males (8.01 mu g/L) and in drinkers (9.67 mu g/L) compared to non-drinkers (8.38 mu g/L). The other variables did not change the Mn data. Selenium concentrations did not differ significantly as a function of individuals factors. With reference to Zn, males had GM of 6804 mu g/L and females of 6031 mu g/L, and more blood Zn was found in subjects consuming alcohol (6618 mu g/L) respect to abstainers (6155 mu g/L). In addition, blood Zn was not affected by age, smoking habit and place of living. (C) 2010 Elsevier GmbH. All rights reserved.