Clinical Features, Risk Factors, and Complications Among Pediatric Patients With Pandemic Influenza A (H1N1)
Clinical Features, Risk Factors, and Complications Among Pediatric Patients With Pandemic Influenza A (H1N1)
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DOI：
10.1177/0009922810368558
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发表时间：
2010-08-01
影响因子：
1.6
通讯作者：
Falagas, Matthew E.
中科院分区：
文献类型：
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作者：
Plessa, Eleni;Diakakis, Panagiotis;Falagas, Matthew E.
目标。这组作者的目的是描述实验室确诊的甲型H1N1大流行性流感儿童的流行病学特征、临床特征、严重疾病的危险因素和并发症。方法。对口咽拭子标本进行逆转录聚合酶链反应（RT-PCR）测定，证实为甲型H1N1流感。回顾性回顾了一部分被评估患者的病历；另一组被纳入前瞻性研究。结果。共有51例患者（44例[86%]，年龄50岁）被确定为实验室确诊的H1N1。发热是最常见的症状（92%）。在15名住院患者中，4名患有哮喘，5名超重或肥胖。除1名患者外，这9名患者均出现流感相关并发症。总体而言，15名住院患者中有10名（67%）出现流感相关并发症（6名支气管炎和4名肺炎）。结论。在这个队列中，大多数确诊H1N1感染的儿童经历了一种无并发症的病毒性疾病。然而，潜在的哮喘和肥胖可能会加重其临床病程。
Objective. The authors aimed to describe the epidemiological characteristics, clinical features, risk factors for severe disease, and complications in children with laboratory-confirmed pandemic influenza A (H1N1). Methods. H1N1 was confirmed by performing reverse-transcriptase polymerase chain reaction (RT-PCR) assay on oropharyngeal swab specimens. The medical charts of a subset of the evaluated patients were reviewed retrospectively; another subset was enrolled prospectively. Results. A total of 51 patients (44 [86%] > 5 years) were identified to have laboratory-confirmed H1N1. Fever was the most common presenting symptom (92%). Of the 15 hospitalized patients, 4 had asthma, and 5 were overweight or obese. All but 1 of these 9 patients developed influenza-related complications. Overall, 10 of the 15 hospitalized patients (67%) developed an influenza-related complication (6 bronchitis and 4 pneumonia). Conclusion. In this cohort, most children with confirmed H1N1 infection experience an uncomplicated viral illness. Nevertheless, underlying asthma and obesity may aggravate their clinical course.