Efficacy and Safety of Percutaneous Ozone Injection Around Gasserian Ganglion for the Treatment of Trigeminal Neuralgia: A Multicenter Retrospective Study
Efficacy and Safety of Percutaneous Ozone Injection Around Gasserian Ganglion for the Treatment of Trigeminal Neuralgia: A Multicenter Retrospective Study
复制标题
半月神经节周围经皮臭氧注射治疗三叉神经痛的疗效和安全性：多中心回顾性研究
DOI：
10.2147/jpr.s232081
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发表时间：
2020-01-01
影响因子：
2.7
通讯作者：
An, Jian-Xiong
中科院分区：
文献类型：
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作者：
Gao, Lei;Chen, Ruo-Wen;An, Jian-Xiong
背景：据报道，三叉神经痛（TN）的有效治疗方法是在Gasserian ganglion （OIAGG）周围注射臭氧。然而，仍有需要改进的地方。为了克服这些限制之一，对应用程序进行多中心检查将非常有帮助。目的本报告的目的是评估OIAGG在多个中心治疗难治性TN的疗效，并探讨成功治疗的预测因素。设计一项多中心回顾性研究。这项研究是在中国的三个疼痛中心进行的。患者与方法来自3个疼痛中心的103名受试者被纳入研究。在c臂x线引导下，将浓度为30µg/mL的臭氧-氧气混合气体注入Gasserian神经节周围区域。主要结果测量包括使用视觉模拟量表（VAS）和Barrow神经学研究所（BNI）疼痛强度量表进行疼痛评估。在OIAGG前、治疗后、6个月、1年和2年对患者进行这些结果测量的临床评估。结果成功的疼痛缓解被定义为BNI评分I-IIIa级。术后6个月、1年、2年疼痛缓解率分别为88.35%、86.87%、84.46%、83.30%。各观察时间点VAS评分与术前比较差异均有统计学意义（P<0.05）。Logistic回归分析显示既往神经损伤对治疗结果有显著影响。治疗期间和治疗后均未发现明显的并发症和副作用。结论本次多中心研究证实了我们之前的单中心研究结果，OIAGG对TN患者既有效又安全。
Background Ozone injection around Gasserian ganglion (OIAGG) has been reported to be an effective treatment for trigeminal neuralgia (TN); however, there remain areas for improvement. To overcome one of these limitations, a multicenter examination of application would be extremely helpful. Objective The goal of this report was to assess the efficacy of OIAGG for refractory TN across multiple centers and to explore factors predictive of successful treatment. Design A multicenter, retrospective study. Setting The study was conducted across 3 pain centers across China. Patients and Methods A total of 103 subjects from 3 pain centers were enrolled in the study. An ozone-oxygen mixture gas at a concentration of 30 µg/mL was injected into the area around the Gasserian ganglion performed under C-arm X-ray guidance. Primary outcome measures included a pain assessment using a visual analog scale (VAS) and the Barrow Neurological Institute (BNI) pain intensity scale. Clinical assessment of patients for these outcome measures was performed at pretreatment, post-treatment, 6 months, 1 year and 2 years after the OIAGG. Results Successful pain relief was defined as a score within BNI grades I–IIIa. The pain relief rates at post-treatment, 6 months, 1 year and 2 years after the procedure were 88.35%, 86.87%, 84.46% and 83.30%, respectively. The VAS at each observation time point was significantly different from the preoperative levels (P<0.05). Logistic regression analysis showed that previous nerve damage had a significant effect on the treatment results. No significant complications or side effects were found during or after treatment. Conclusion This multicenter research confirms our previous single center results that OIAGG is both effective and safe for patients with TN.