Combined chemoradiotherapy vs. radiotherapy alone for early stage squamous cell carcinoma of the esophagus: A study of the Eastern Cooperative Oncology Group
Combined chemoradiotherapy vs. radiotherapy alone for early stage squamous cell carcinoma of the esophagus: A study of the Eastern Cooperative Oncology Group
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DOI：
10.1016/s0360-3016(98)00232-6
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发表时间：
1998-09-01
影响因子：
7
通讯作者：
Sischy, B
中科院分区：
文献类型：
--
作者：
Smith, TJ;Ryan, LM;Sischy, B
胸段食管鳞状细胞癌预后极差。这项研究，EST-1282，是由东部肿瘤协作组（ECOG）进行的，以确定联合使用5-氟尿嘧啶（5-FU），丝裂霉素C和放射治疗是否改善了食管癌患者的无病生存期和总生存期，与那些只接受放射治疗的患者相比，单纯放疗组的2年和5年生存率分别为12%和7%，放化疗组分别为27%和9%。（14.8个月），与单独接受放射治疗的患者（9.2个月）相比，该差异具有统计学意义。在几乎所有的亚组中观察到相同的生存模式，而与是否进行手术切除无关。(C)1998年爱思唯尔科学公司
Squamous carcinoma of the thoracic esophagus has an extremely poor prognosis. This study, EST-1282, was undertaken by the Eastern Cooperative Oncology Group (ECOG) to determine whether the combined use of 5-fluorouracil (5-FU), mitomycin C, and radiation therapy improved the disease-free survival and overall survival of patients with carcinoma of the esophagus, compared to those who received radiation therapy alone, Two- and 5-year survivals were 12% and 7% in the radiation alone arm and 27% and 9% in the chemoradiation arm. Patients treated with chemoradiation had a longer median survival (14.8 months), compared to patients receiving radiation therapy alone (9.2 months), This difference was statistically significant. The same pattern of survival was noted in almost all subgroups independent of whether surgical resection was performed. (C) 1998 Elsevier Science Inc.