A-methylacyl-CoA racemase (AMACR) and prostate-cancer risk: a meta-analysis of 4,385 participants.
A-methylacyl-CoA racemase (AMACR) and prostate-cancer risk: a meta-analysis of 4,385 participants.
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DOI：
10.1371/journal.pone.0074386
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Zhou L
中科院分区：
文献类型：
--
作者：
Jiang N;Zhu S;Chen J;Niu Y;Zhou L
α -甲基酰基辅酶a消旋酶（AMACR）是一种在前列腺癌中过表达的线粒体和过氧化物酶体酶。本研究的目的是证实和扩展在不同地理区域与AMACR表达相关的男性患PCa风险增加的研究结果。系统地检索了数据库，并查明了其他有关文章。然后根据标准指南进行meta分析。根据纳入标准，共纳入了22项研究，共有4385名参与者。IHC检测的AMACR与PCa诊断增加显著相关（OR = 76.08; 95% CI, 25.53-226.68； P<0.00001）。亚组分析显示，仅考虑白种人或亚洲人（or = 51.23; 95% CI, 19.41-135.24； P<0.00001）时，结果没有显著变化。PCR检测AMACR与PCa风险的关系提示AMACR与PCa相关（OR = 33.60; 95% CI, 4.67 ~ 241.77； P<0.00001）。也没有观察到显著的发表偏倚。我们的研究结果进一步证明了AMACR的表达与PCa风险有关。AMACR蛋白在前列腺癌中呈过表达，在任何正常组织或良性前列腺组织中均呈低表达。AMACR可能是一个重要的前列腺肿瘤标志物。
Alpha-methylacyl-CoA racemase (AMACR) is a mitochondrial and peroxisomal enzyme that is overexpressed in prostate cancer. The aim of this study was to confirm and expand the findings that the PCa risk increased in men associated with AMACR expression across various geographic regions. A systematic search of databases was carried out and other relevant articles were also identified. Then the meta-analyses were conducted according to the standard guidelines. A total of 22 studies with 4,385 participants were included on the basis of inclusion criteria. AMACR by IHC was significantly associated with increased diagnosis of PCa (OR = 76.08; 95% CI, 25.53–226.68; P<0.00001). Subgroup-analysis showed that findings didn’t substantially change when only Caucasians or Asians (OR = 51.23; 95% CI, 19.41–135.24; P<0.00001) were considered. Expression of AMACR by PCR in relation to PCa risk suggested that AMACR was associated with PCa (OR = 33.60; 95% CI, 4.67–241.77; P<0.00001). There was also no significant publication bias observed. Our findings provide further evidences that the expression of AMACR contribute to PCa risk. AMACR protein overexpression was found in prostate cancers, low expression in any of the normal tissues or in benign prostatic tissue. AMACR is potentially an important prostate tumor marker.
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影响因子：
15.8
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
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影响因子：
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作者：
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作者：
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通讯作者：
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作者：
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影响因子：
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作者：
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