Two types of hydrophobic aggregates in aqueous solutions of chitosan and its hydrophobic derivative
Two types of hydrophobic aggregates in aqueous solutions of chitosan and its hydrophobic derivative
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DOI：
10.1021/bm005649a
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发表时间：
2001-06-01
影响因子：
6.2
通讯作者：
Rinaudo, M
中科院分区：
文献类型：
--
作者：
Philippova, OE;Volkov, EV;Rinaudo, M
以芘为探针，用粘度法和荧光光谱法研究了含4摩尔%正十二烷基侧链的疏水改性壳聚糖（HM）水溶液中的聚集现象。并与未改性壳聚糖进行了比较。令人惊讶的是，荧光数据揭示了壳聚糖和HM壳聚糖中分子间疏水聚集体的出现。然而，这些聚合物表现出完全不同的流变特性：在形成聚集体时，HM壳聚糖的粘度急剧增加，而未改性的壳聚糖的粘度仅略有增加。提出了壳聚糖及其疏水衍生物的聚合模型。结果表明，在HM壳聚糖溶液中存在两种类型的疏水结构域：具有疏水侧链的不同缔合聚合物特有的疏水结构域和壳聚糖本身固有的疏水结构域。
The aggregation phenomena in aqueous solutions of hydrophobically modified (HM) chitosan, containing 4 mol % of n-dodecyl side chains, were studied by viscometry and fluorescence spectroscopy with pyrene as a probe. The results are compared with those for unmodified chitosan. Surprisingly, fluorescence data reveal the appearance of intermolecular hydrophobic aggregates both in chitosan and in HM chitosan. Nevertheless, these polymers exhibit quite different rheological properties: upon the formation of aggregates the viscosity of HM chitosan sharply increases, while that of unmodified chitosan raises only slightly. The aggregation models for both chitosan and its hydrophobic derivative were proposed. It was shown that in solutions of HM chitosan two types of hydrophobic domains exist: hydrophobic domains typical for different associating polymers with hydrophobic side chains and hydrophobic domains inherent to chitosan itself.