The Microenvironmental Effect in the Progression, Metastasis, and Dormancy of Breast Cancer: A Model System within Bone Marrow.
The Microenvironmental Effect in the Progression, Metastasis, and Dormancy of Breast Cancer: A Model System within Bone Marrow.
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DOI：
10.1155/2012/721659
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发表时间：
2012
影响因子：
1.9
通讯作者：
Rameshwar P
中科院分区：
文献类型：
--
作者：
Reddy BY;Lim PK;Silverio K;Patel SA;Won BW;Rameshwar P
尽管在诊断方面取得了进步，但乳腺癌仍然是美国女性中最常见的癌症。转移性疾病的治疗选择是有限的，并且在根除癌症方面大多无效。然而，在最近的文献中有新的发现，证实了微环境在乳腺癌进展中的作用，并支持转移到三级部位，如骨髓。微环境在乳腺癌转移的病理生理学中的重要性已经被发现，这对以前广泛传播的理论提出了挑战，并为未来根除乳腺癌的研究引入了新的视角。本文阐述了目前对乳腺癌细胞与微环境在进展、转移和休眠中相互作用的分子机制的理解。除了骨髓中描述的其他机制外，本文还讨论了这些信息。
Despite diagnostic advances, breast cancer remains the most prevalent cancer among women in the United States. The armamentarium of treatment options for metastatic disease is limited and mostly ineffective with regards to eradicating cancer. However, there have been novel findings in the recent literature that substantiate the function of the microenvironment in breast cancer progression and the support of metastasis to tertiary sites such as bone marrow. The uncovered significance of the microenvironment in the pathophysiology of breast cancer metastasis has served to challenge previously widespread theories and introduce new perspectives for the future research to eradicate breast cancer. This paper delineates the current understanding of the molecular mechanisms involved in the interactions between breast cancer cells and the microenvironment in progression, metastasis, and dormancy. The information, in addition to other mechanisms described in bone marrow, is discussed in the paper.