AtMSL9 and AtMSL10 Sensors of plasma membrane tension in Arabidopsis roots
AtMSL9 and AtMSL10 Sensors of plasma membrane tension in Arabidopsis roots
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DOI：
10.4161/psb.3.9.6487
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发表时间：
2008-01-01
影响因子：
2.9
通讯作者：
Frachisse, Jean-Marie
中科院分区：
文献类型：
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作者：
Peyronnet, Remi;Haswell, Elizabeth S.;Frachisse, Jean-Marie
植物细胞，像动物和细菌一样，能够感知质膜的物理变形。机械敏感（MS）通道是将机械力转化为离子流的蛋白质，提供了感知机械刺激（如声音、触觉和渗透压）的机制。我们最近确定AtMSL 9和AtMSL 10，两个机械敏感通道拟南芥，作为分子候选人在高等植物中的机械传感。(1)AtMSL 9和AtMSL 10是拟南芥中与细菌MS通道MscS相关的蛋白质家族的成员，称为MscS-Like（或MSL）。(2)小电导机械敏感通道（MscS）是最早被发现存在于巨噬细胞质膜上的一种电生理活性通道。coli原生质球。（3，4）MscS的激活是电压依赖性的，但直接响应于施加到膜上的张力，并且不需要其他细胞蛋白来进行这种调节。（5，6）MscS家族成员广泛分布于细菌和古细菌基因组中，存在于所有已检测的植物基因组中，并在选定的真菌基因组中发现。（2，7，8）尚未在动物中鉴定出MscS同源物。
Plant cells, like those of animals and bacteria, are able to sense physical deformation of the plasma membrane. Mechanosensitive (MS) channels are proteins that transduce mechanical force into ion flux, providing a mechanism for the perception of mechanical stimuli such as sound, touch and osmotic pressure. We recently identified AtMSL9 and AtMSL10, two mechanosensitive channels in Arabidopsis thaliana, as molecular candidates for mechanosensing in higher plants.(1) AtMSL9 and AtMSL10 are members of a family of proteins in Arabidopsis that are related to the bacterial MS channel MscS, termed MscS-Like (or MSL).(2) MscS (Mechanosensitive channel of Small conductance) is one of the best-characterized MS channels, first identified as an electrophysiological activity in the plasma membrane (PM) of giant E. coli spheroplasts.(3,4) Activation of MscS is voltage-independent, but responds directly to tension applied to the membrane and does not require other cellular proteins for this regulation.(5,6) MscS family members are widely distributed throughout bacterial and archaeal genomes, are present in all plant genomes yet examined, and are found in selected fungal genomes.(2,7,8) MscS homolgues have not yet been identified in animals.