Fibroblast growth factors in epithelial repair and cytoprotection
Fibroblast growth factors in epithelial repair and cytoprotection
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DOI：
10.1098/rstb.2004.1464
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发表时间：
2004-05-29
影响因子：
6.3
通讯作者：
Werner, S
中科院分区：
文献类型：
--
作者：
Braun, S;Keller, UAD;Werner, S
生长因子是在低浓度下刺激某些细胞类型分裂的多肽。成纤维细胞生长因子（FGF）7（FGF-7）及其同系物FGF-10特异性作用于各种类型的上皮细胞，包括皮肤的角质形成细胞、肠上皮细胞和肝细胞。此外，FGF-7和FGF-10已被证明不仅仅是生长因子：它们可以保护上皮细胞免受例如由辐射和氧化应激诱导的损伤作用。因此，它们目前正处于治疗口腔粘膜炎的临床试验中，口腔粘膜炎是癌症治疗的严重副作用，其特征在于口腔上皮的疼痛性炎症和溃疡。为了深入了解FGF-7/FGF-10在上皮细胞中的作用机制，我们寻找了受这些生长因子调控的基因。事实上，我们确定了有助于我们解释FGF-7作用机制的基因。最有趣的是，几个基因被确定为可能介导FGF-7的细胞保护作用的上皮细胞在体外，也可能在体内受伤和患病的组织。
Growth factors are polypeptides that stimulate the division of certain cell types at low concentrations. Fibroblast growth factor (FGF) 7 (FGF-7) and its homologue FGF-10 act specifically on various types of epithelial cells including keratinocytes of the skin, intestinal epithelial cells and hepatocytes. In addition, FGF-7 and FGF-10 have been shown to be more than growth factors: they can protect epithelial cells from damaging effects induced, for example, by radiation and oxidative stress. Therefore, they are currently in clinical trials for the treatment of oral mucositis, a severe side-effect of cancer therapy characterized by painful inflammation and ulceration of the oral epithelium. To gain insight into the mechanisms of FGF-7/FGF-10 action in epithelial cells, we searched for genes that are regulated by these growth factors. Indeed, we identified genes that help us to explain the mechanisms that underlie the effects of FGF-7. Most interestingly, several genes were identified that are likely to mediate the cytoprotective effect of FGF-7 for epithelial cells in vitro and possibly also in injured and diseased tissues in vivo.