The epidemiology of Chlamydia trachomatis within a sexually transmitted diseases core group
The epidemiology of Chlamydia trachomatis within a sexually transmitted diseases core group
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DOI：
10.1093/infdis/173.4.950
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发表时间：
1996-04-01
影响因子：
6.4
通讯作者：
Plummer, FA
中科院分区：
文献类型：
--
作者：
Brunham, RC;Kimani, J;Plummer, FA
对内罗毕的女性性工作者进行了前瞻性的沙眼衣原体感染的危险因素评估。独立危险因素包括宫颈异位（P = .007）、淋球菌感染（P = .002）、人类免疫缺陷病毒（HIV）血清阳性（P = .003）、HIV血清转换（P = .001）和卖淫时间（P = .002）。沙眼衣原体感染率随时间变化显著（P = 0.005），19例间隔≥ 6个月的再次感染者中17例C.沙眼衣原体omp1基因型，HIV感染的妇女与C。沙眼衣原体感染（P = 0.001）和再感染风险增加（P = 0.008）。总体而言，数据表明沙眼衣原体人群的基因型组成存在显著波动，相同基因型再感染率降低与菌株特异性免疫的发生一致。
Female sex workers in Nairobi were prospectively evaluated for risk factors of incident Chlamydia trachomatis infection. Independent risk factors included cervical ectopy (P = .007), gonococcal infection (P = .002), human immunodeficiency virus (HIV) seropositivity (P = .003), HIV seroconversion (P = .001), and duration of prostitution (P = .002), Eighteen different C, trachomatis outer membrane protein (omp1) genotypes were identified, with the allelic composition of the C. trachomatis population changing significantly over time (P = .005), Seventeen of 19 reinfections greater than or equal to 6 months apart were with different C. trachomatis omp1 genotypes, Women with HIV infection had an increased proportion of visits with C. trachomatis infection (P = .001) and an increased risk of reinfection (P = .008), Overall, the data demonstrate significant fluctuations in the genotype composition of the C, trachomatis population and a reduced rate of same-genotype reinfection consistent with the occurrence of strain-specific immunity.