CYTO-TOXIC T-CELLS IN CYTOMEGALOVIRUS-INFECTION - HLA-RESTRICTED LYMPHOCYTE-T AND NON-T-LYMPHOCYTE CYTO-TOXIC RESPONSES CORRELATE WITH RECOVERY FROM CYTOMEGALOVIRUS-INFECTION IN BONE-MARROW-TRANSPLANT RECIPIENTS
CYTO-TOXIC T-CELLS IN CYTOMEGALOVIRUS-INFECTION - HLA-RESTRICTED LYMPHOCYTE-T AND NON-T-LYMPHOCYTE CYTO-TOXIC RESPONSES CORRELATE WITH RECOVERY FROM CYTOMEGALOVIRUS-INFECTION IN BONE-MARROW-TRANSPLANT RECIPIENTS
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DOI：
10.1056/nejm198207013070102
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发表时间：
1982-01-01
影响因子：
158.5
通讯作者：
BURNS, WH
中科院分区：
文献类型：
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作者：
QUINNAN, GV;KIRMANI, N;BURNS, WH
研究了58例骨髓移植受者，以评估巨细胞病毒感染的免疫应答。43名患者发生了此类感染; 12名患者死亡，23名患者非致命，8名患者因其他原因死亡。所有患者感染前巨细胞病毒特异性细胞毒淋巴细胞活性低或缺乏。所有存活者均产生巨细胞病毒特异性细胞毒反应，仅2例致死性感染患者产生较低水平的巨细胞病毒特异性细胞毒反应。自然和抗体依赖性巨噬细胞的活动在感染前和感染期间都受到抑制，但在那些存活的患者中则没有。感染的结果与基础疾病的性质、接受的移植类型、移植前巨细胞病毒抗体状态或对巨细胞病毒抗原或伴刀豆球蛋白A的淋巴细胞增殖反应无关。有效的病毒特异性细胞毒性反应和从感染中恢复之间的相关性表明，这些效应细胞可能介导从巨细胞病毒感染中恢复。
Recipients (58) of bone-marrow transplants were studied to evaluate immune responses to cytomegalovirus infection. Such infection developed in 43 patients; it was fatal in 12, nonfatal in 23 and present at death from other causes in 8. All patients had low or absent cytomegalovirus-specific cytotoxic lymphocyte activity before the onset of infection. Cytomegalovirus-specific cytotoxic responses developed in all survivors, only 2 patients with fatal infection had even low-level cytomegalovirus-specific cytotoxic responses. Natural and antibody-dependent killer-cell activities were depressed both before and during infection in patients with fatal infections, but not in those who survived. The outcome of the infection did not correlate with the nature of the underlying disease, the type of transplant received, the pretransplantation cytomegalovirus-antibody status or lymphocyte-proliferation responses to cytomegalovirus antigens or concanavalin A. The correlation between effective virus-specific cytotoxic response and recovery from infection indicates that these effector cells probably mediate recovery from cytomegalovirus infection.