Organocatalytic Asymmetric Alkylation of Aldehydes by SN1-Type Reaction of Alcohols
Organocatalytic Asymmetric Alkylation of Aldehydes by SN1-Type Reaction of Alcohols
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DOI：
10.1002/anie.200805423
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发表时间：
2009-01-01
影响因子：
16.6
通讯作者：
Zoli, Luca
中科院分区：
文献类型：
--
作者：
Cozzi, Pier Giorgio;Benfatti, Fides;Zoli, Luca
工作-酒精！难以捉摸的对映选择性催化醛的α-烷基化反应，这是一种广泛寻求的转化，是通过使用能够形成稳定的碳正离子的醇来实现的(见方案，tFA=三氟乙酸)。
Work‐alcoholic!The elusive enantioselective catalytic α‐alkylation of aldehydes, a widely sought transformation, was brought to execution by the use of alcohols capable of forming stabilized carbocations (see scheme, TFA=trifluoroacetic acid).