Cerebral function in posttraumatic stress disorder during verbal working memory updating: A positron emission tomography study
Cerebral function in posttraumatic stress disorder during verbal working memory updating: A positron emission tomography study
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DOI：
10.1016/s0006-3223(02)01505-6
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发表时间：
2003-03-15
影响因子：
10.6
通讯作者：
Egan, GF
中科院分区：
文献类型：
--
作者：
Clark, CR;McFarlane, AC;Egan, GF
背景：本研究考察了创伤后应激障碍（PTSD）患者工作记忆向创伤中性语言信息更新过程中的脑功能。方法：10名创伤后应激障碍被试和匹配的对照组分别完成连续更新（可变目标条件）或不更新（固定目标条件）目标身份的视觉全局目标检测任务，通过条件比较估计目标身份的更新活动。结果：使用这种模式的正常更新活动涉及双侧背外侧前额叶皮层（DLPFC）和下顶叶的激活。PTSD组在左半球缺乏这种激活，在这方面与对照组显著不同，但在双侧的上顶叶显示出额外的激活。结论：顶叶激活模式表明，创伤中性语言信息的工作记忆表征依赖于视觉空间编码。DLPFC相对参与的组间差异表明，PTSD患者对通常归因于左DLPFC在脑后区监测和操纵工作记忆内容的执行作用的依赖程度较低。(C) 2003年生物精神病学学会。
Background: This study examined cerebral function in posttraumatic stress disorder (PTSD) during the updating of working memory to trauma-neutral, verbal information.Methods: Ten PTSD and matched control subjects completed a visuoverbal target detection task involving continuous updating (Variable target condition) or no updating (Fixed target condition) of target identity, with updating activity estimated by condition comparison.Results: Normal updating activity using this paradigm involved bilateral activation of the dorsolateral prefrontal cortex (DLPFC) and inferior parietal lobe. The PTSD group lacked this activation in the left hemisphere and was significantly different from control subjects in this regard, but showed additional activation in the superior parietal lobe, bilaterally.Conclusions: The pattern of parietal activation suggests a dependence on visuospatial coding for working memory representation of trauma-neutral, verbal information. Group differences in the relative involvement of the DLPFC indicate less dependence in PTSD on the executive role normally attributed to the left DLPFC for monitoring and manipulation of working memory content in posterior regions of the brain. (C) 2003 Society of Biological Psychiatry.