Hyperglycemia, a neglected factor during cancer progression.
Hyperglycemia, a neglected factor during cancer progression.
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DOI：
10.1155/2014/461917
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发表时间：
2014
影响因子：
--
通讯作者：
Ma Q
中科院分区：
文献类型：
--
作者：
Duan W;Shen X;Lei J;Xu Q;Yu Y;Li R;Wu E;Ma Q
最近来自大型队列研究的证据表明，2型糖尿病（DM2）患者的癌症发病率较高。然而，迄今为止，这种关联的潜在原因仍不清楚。糖尿病最重要的特征是高血糖，它可能导致这些葡萄糖饥饿细胞的过量葡萄糖供应，并且它有助于细胞凋亡抗性、肿瘤发生和肿瘤细胞对化疗的抗性。考虑到糖尿病与恶性肿瘤之间的关系，血糖异常的癌症患者中高血糖对癌症进展的影响不应被忽视。在本文中，我们描述了高血糖症在癌症进展和治疗中的作用，并说明高血糖症可能导致癌细胞的恶性表型并导致耐药性。因此，控制高血糖可能对癌症患者具有重要的治疗意义。
Recent evidence from large cohort studies suggests that there exists a higher cancer incidence in people with type 2 diabetes (DM2). However, to date, the potential reasons for this association remain unclear. Hyperglycemia, the most important feature of diabetes, may be responsible for the excess glucose supply for these glucose-hungry cells, and it contributes to apoptosis resistance, oncogenesis, and tumor cell resistance to chemotherapy. Considering associations between diabetes and malignancies, the effect of hyperglycemia on cancer progression in cancer patients with abnormal blood glucose should not be neglected. In this paper, we describe the role that hyperglycemia plays in cancer progression and treatment and illustrate that hyperglycemia may contribute to a more malignant phenotype of cancer cells and lead to drug resistance. Therefore, controlling hyperglycemia may have important therapeutic implications in cancer patients.