ISCHEMIA REPERFUSION INJURY - A REVIEW
ISCHEMIA REPERFUSION INJURY - A REVIEW
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DOI：
10.1002/micr.1920140307
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发表时间：
1993-01-01
期刊：
影响因子：
2.1
通讯作者：
STOTLAND, MA
中科院分区：
文献类型：
--
作者：
KERRIGAN, CL;STOTLAND, MA
本文回顾了近十年来皮瓣研究的发展历程。一个描述的临床相关性这一领域提出和可能的病因进行了审查。然后详细探讨这种损伤的病理生理学。在各种动物模型中，讨论了皮肤和肌皮瓣。在体外进行的研究，以及在其他器官系统类似地影响缺血和再灌注，也进行了检查。特别关注的是几种新描述的炎症介质的功能，它似乎与重建显微外科领域的未来研究和治疗有关。
Ischemia reperfusion injury is reviewed in the context of the evolution of flap research over the past decade. A description of the clinical relevance of this field is presented and the possible etiologies are reviewed. The pathophysiology of this injury is then explored in some detail. Both skin and myocutaneous flaps, in a variety of animal models, are discussed. Research performed in vitro, as well as in other organ systems similarly affected by ischemia and reperfusion, is also examined. Particular attention is placed on the function of several newly described inflammatory mediators where it appears relevant to future research and treatment in the field of reconstructive microsurgery.