Risk Assessment and Safety Evaluation Study for Ozonolysis of β-Pinene: Raw Material of a Novel Prostaglandin D2 Receptor Antagonist S-5751
Risk Assessment and Safety Evaluation Study for Ozonolysis of β-Pinene: Raw Material of a Novel Prostaglandin D2 Receptor Antagonist S-5751
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DOI：
10.1021/op100065d
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发表时间：
2010-11-01
影响因子：
3.4
通讯作者：
Nogusa, Hideo
中科院分区：
文献类型：
--
作者：
Hida, Takemasa;Kikuchi, Junko;Nogusa, Hideo
采用DSC、ARC和RC 1 e对β-蒎烯的臭氧化反应进行了安全性评价。ARC测试表明，臭氧化混合物的浓度影响其热稳定性。在1.83mol/L的高浓度下，样品即使在室温下也非常不稳定，并且迅速分解。0.73 mol/L稀释样品的ADT（24）为28.2 ℃。尽管由于反应热的积累，臭氧化混合物在极低温度下的还原分解是非常危险的，但其工艺温度经验证不超过ADT（24）。因此，可以实现300 L反应器规模的中试生产。
Safety evaluation for ozonolysis of beta-pinene was conducted using DSC, ARC, and RC1e. ARC measurement showed that the concentration of the ozonized mixture affects its thermal stability. The sample at a high concentration of 1.83 mol/L was very unstable even at room temperature and decomposed rapidly. ADT(24) of the diluted sample of 0.73 mol/L was 28.2 degrees C. Although reductive decomposition of the ozonized mixture at extremely low temperature is very dangerous because of accumulation of the heat of reaction, its process temperature was validated to not exceed the ADT(24). As a result, pilot manufacturing on a 300-L reactor scale could be achieved.