Dietary Intakes of Retinol, Carotenes, Vitamin C, and Vitamin E and Colorectal Cancer Risk: The Fukuoka Colorectal Cancer Study
Dietary Intakes of Retinol, Carotenes, Vitamin C, and Vitamin E and Colorectal Cancer Risk: The Fukuoka Colorectal Cancer Study
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DOI：
10.1080/01635581.2012.690927
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发表时间：
2012-01-01
影响因子：
2.9
通讯作者：
Terasaka, Reiji
中科院分区：
文献类型：
--
作者：
Wang, Zhenjie;Joshi, Amit Man;Terasaka, Reiji
抗氧化维生素是否能预防结直肠癌以及一般的人类癌症一直是一个令人感兴趣的问题，但流行病学证据并不确定。我们在日本福冈结直肠癌研究中随机选择了816例经组织学证实的结直肠癌病例和815例对照，研究了饮食中视黄醇和抗氧化维生素摄入量与结直肠癌风险的关系。膳食摄入量进行了评估，由PC辅助采访有关148种食物。对体重指数、体力活动、钙和n-3脂肪酸摄入量等因素进行统计调整。视黄醇摄入量与结直肠癌风险显著负相关;女性中最高与最低的比值比为0.55（95% CI：0.35，0.88; P趋势= 0.01），但在视黄醇摄入量最高的男性中观察到风险适度增加。肝脏是视黄醇摄入的主要来源，并且在男性和女性中显示出与结直肠癌风险相似的相关性。胡萝卜素、维生素C和维生素E的摄入量与男性或女性的结直肠癌风险无关。这项研究并不支持饮食中摄入抗氧化维生素对结直肠癌的发展具有保护作用的假设。
It has long been a matter of interest whether antioxidant vitamins are protective against colorectal cancer as well as human cancers in general, but epidemiological evidence is inconclusive. We investigated associations of dietary intakes of retinol and antioxidant vitamins with colorectal cancer risk in 816 incident cases of histologically confirmed colorectal cancer and 815 controls randomly selected for the Fukuoka colorectal cancer study in Japan. Dietary intakes were assessed by a PC-assisted interview regarding 148 food items. Statistical adjustment was made for body mass index, physical activity, calcium, and n-3 fatty acid intake and other factors. Retinol intake was significantly, inversely associated with colorectal cancer risk; the odds ratio for the highest vs. lowest was 0.55 (95% CI: 0.35, 0.88; P-trend = 0.01) in women, but a modest increase in the risk was observed among men with the highest intake of retinol. Liver was the major source of retinol intake and showed similar associations with colorectal cancer risk in men and women. Intake of carotenes, vitamin C, and vitamin E were not related to colorectal cancer risk in either men or women. The study did not support a hypothesis that dietary intake of antioxidant vitamins is protective in the development of colorectal cancer.