An Essential Role of Small Ubiquitin-like Modifier (SUMO)-specific Protease 2 in Myostatin Expression and Myogenesis
An Essential Role of Small Ubiquitin-like Modifier (SUMO)-specific Protease 2 in Myostatin Expression and Myogenesis
复制标题
小泛素样修饰剂 (SUMO) 特异性蛋白酶 2 在肌生长抑制素表达和肌生成中的重要作用
DOI：
10.1074/jbc.m113.518282
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发表时间：
2014-02-07
影响因子：
4.8
通讯作者：
Cheng, Jinke
中科院分区：
文献类型：
--
作者：
Qi, Yitao;Zuo, Yong;Cheng, Jinke
Background: It is unknown whether SUMOylation regulates myogenesis in skeletal muscle. Results: SENP2 de-SUMOylates MEF2A, promoting myostatin expression and suppressing myogenesis in skeletal muscle. Conclusion: SENP2 plays a critical role in the regulation of myostatin-induced inhibition of myogenesis. Significance: SENP2 is a potential therapeutic target in skeletal muscle regeneration.Sentrin/small ubiquitin-like modifier (SUMO)-specific protease 2 (SENP2) has broad de-SUMOylation activities in vitro, which is essential for embryonic heart development. Here, we show that myostatin, a key factor in skeletal muscle development, is markedly reduced in Senp2(-/-) mouse embryonic fibroblast cells and embryos. SENP2 regulates the transcription of myostatin mainly through de-SUMOylation of MEF2A. Silencing SENP2 can reduce myostatin expression and, therefore, promote myogenesis of skeletal muscle. These results reveal the important role of SENP2 in the regulation of myostatin expression and myogenesis.
