Epigenetic stem cell signature in cancer
Epigenetic stem cell signature in cancer
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DOI：
10.1038/ng1941
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发表时间：
2007-02-01
期刊：
影响因子：
30.8
通讯作者：
Laird, Peter W.
中科院分区：
文献类型：
--
作者：
Widschwendter, Martin;Fiegl, Heidi;Laird, Peter W.
胚胎干细胞依赖于Polycomb组蛋白可逆地抑制分化所需的基因。我们报告说，干细胞Polycomb组靶标具有癌症特异性启动子DNA超甲基化的可能性比非靶标高12倍，支持癌症的干细胞起源，其中可逆的基因抑制被永久沉默取代，将细胞锁定在自我更新的永久状态中，从而诱发随后的恶性转化。
Embryonic stem cells rely on Polycomb group proteins to reversibly repress genes required for differentiation. We report that stem cell Polycomb group targets are up to 12-fold more likely to have cancer- specific promoter DNA hypermethylation than non-targets, supporting a stem cell origin of cancer in which reversible gene repression is replaced by permanent silencing, locking the cell into a perpetual state of self-renewal and thereby predisposing to subsequent malignant transformation.