Genetic characterization of Puumala hantavirus strains from Belgium: evidence for a distinct phylogenetic lineage
Genetic characterization of Puumala hantavirus strains from Belgium: evidence for a distinct phylogenetic lineage
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DOI：
10.1016/s0168-1702(00)00224-0
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发表时间：
2001-04-01
期刊：
影响因子：
5
通讯作者：
Plyusnin, A
中科院分区：
文献类型：
--
作者：
Escutenaire, S;Chalon, P;Plyusnin, A
从1996年至1998年在比利时南部四个地点捕获的红岸田鼠（Clethrionomys glareolus）中回收了普马拉汉坦病毒（PUUV）序列：图因：蒙布利亚尔、莫米尼和库万。此外，三个PUUV菌株起源于银行田鼠在20世纪80年代被困在南部（蒙特布利亚尔）和北方（Turnhout）比利时的遗传特征。完整的S和部分M片段序列的分析表明，比利时PUUV菌株构成了一个遗传谱系，不同于欧洲和日本的其他已知PUUV谱系。该谱系还包括源自德国邻近地区的野生菌株（Cg-Erft）。在比利时血统内，观察到遗传变异的地理聚集。在Montbliart网站，时间上最遥远的菌株（1986年和1996-1998年）之间的多样性范围高于1996年和1998年之间的差异，这表明轻微的遗传漂变，通过积累中性或准中性取代随着时间的推移。(C)出版社：Elsevier Science B. V.
Puumala hantavirus (PUUV) sequences were recovered from red bank voles (Clethrionomys glareolus) trapped between 1996 and 1998 in four localities of southern Belgium: Thuin: Montbliart, Momignies and Couvin. In addition, three PUUV isolates originating from bank voles trapped in the 1980s in southern (Montbliart) and northern (Turnhout) Belgium were genetically characterized. Analysis of the complete S and partial M segment sequences showed that the Belgian PUUV strains constitute a genetic lineage, distinct from other known PUUV lineages from Europe and Japan. This lineage also includes a wild strain (Cg-Erft) originating from a neighbouring area of Germany. Within the Belgian lineage, geographical clustering of genetic variants was observed. In the Montbliart site, the range of diversity between the most temporally distant strains (from 1986 and 1996-1998) was higher than between those from 1996 and 1998, suggesting slight genetic drift via accumulation of neutral or quasi-neutral substitutions with time. (C) 2001 Published by Elsevier Science B.V.