Maternal gut microbiota is associated with newborn anthropometrics in a sex-specific manner
Maternal gut microbiota is associated with newborn anthropometrics in a sex-specific manner
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DOI：
10.1017/s2040174419000138
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发表时间：
2019-12-01
影响因子：
1.7
通讯作者：
Mori, Chisato
中科院分区：
文献类型：
--
作者：
Sato, Yumi;Sakurai, Kenichi;Mori, Chisato
母体肠道微生物区系被认为是健康与疾病发育起源(DOHAD)概念中的重要因素之一，但母体肠道微生物区系对胎儿生长发育的影响尚不清楚。在这项研究中，研究了母体肠道微生物区系与胎儿生长的关系。来自千叶母婴健康研究(C-MACH)的51对母婴获得了孕妇和新生儿的信息，以及怀孕后期的粪便样本。用16S rRNA测序分析肠道微生物区系，用气相色谱-串联质谱仪分析粪便中的短链脂肪酸(SCFA)。调整协变量后发现，母体肠道微生物多样性与新生儿男性头围呈正相关(CHO1：调整后r=0.515，p=0.029)。在男性中，Parabacteroidus属和Eggerthella属分别与新生儿头围和体重呈负相关(Parabacteroidus：校正r=-0.598，p=0.009；Eggerthella属：校正r=-0.481，p=0.043)。另一方面，在女性中，链球菌属与新生儿身高呈负相关(调整后r=-0.413，p=0.040)。此外，在单变量分析中，己酸参与了母体肠道微生物区系与新生儿人体测量学之间的关联，但在多变量分析中没有。这些数据表明，母体肠道微生物区系对胎儿生长具有性别特异性的影响。母体肠道微生物区系是宫内最佳生长的重要因素。
Maternal gut microbiota is thought to be one of the important factors in the developmental origins of health and disease (DOHaD) concept, but the effects of maternal gut microbiota on foetal growth are not well known. In this study, the association between maternal gut microbiota and foetal growth was investigated. Maternal and newborn information, as well as stool samples at the third trimester of pregnancy, were obtained from 51 mother-newborn pairs from the Chiba study of Mother and Child Health (C-MACH). Gut microbiota was analysed by 16S rRNA sequencing of stool samples and short-chain fatty acids (SCFAs) in stool were analysed by gas chromatography-tandem mass spectrometry. After adjustment for covariates, it was found that maternal gut microbial diversity had a positive association with head circumference in newborn males (Chao 1: adjusted r = 0.515, p = 0.029). Genus Parabacteroides and genus Eggerthella showed negative associations with newborn head circumference and weight, respectively in males (genus Parabacteroides: adjusted r = -0.598, p = 0.009, genus Eggerthella: adjusted r = -0.481, p = 0.043). On the other hand, genus Streptococcus showed a negative association with newborn height in females (adjusted r = -0.413, p = 0.040). In addition, hexanoate was involved in the association between maternal gut microbiota and newborn anthropometrics in the univariate analysis, but not in the multivariate analysis. These data suggest that maternal gut microbiota has sex-specific effects on foetal growth. Maternal gut microbiota is an important factor for optimal intrauterine growth.