Ankylosing spondylitis: an Australian experience
Ankylosing spondylitis: an Australian experience
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DOI：
10.1111/j.1445-5994.2007.01471.x
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发表时间：
2008-05-01
影响因子：
2.1
通讯作者：
Schachna, L.
中科院分区：
文献类型：
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作者：
Reed, M. D.;Dharmage, S.;Schachna, L.
背景资料：本研究的目的是表征澳大利亚队列强直性脊柱炎（AS）患者和检查重要疾病outcome.Methods的预测因素：横断面研究的患者之间的首次访问数据提到奥斯汀脊柱炎诊所从风湿病学或一般的做法。我们获得了临床和实验室数据，并通过自我报告的questionnaire.Results验证复合指数：AS诊断延迟平均为8.1年，女性和早期发病的疾病更高。女性的颈胸活动性更好，尽管她们表现出更多的附着点压痛和更大的生活质量损害。长期AS患者的疾病活动与近期发病的疾病活动相似，但功能障碍更大。目前吸烟与不良后果，虽然有没有累积暴露和AS outcomes.Conclusion之间的关联：AS在这个第一次描述的澳大利亚队列的临床表现是类似于以前描述的队列。我们观察到女性颈胸段活动度更大，附着点炎指数更高，这可能是导致诊断延迟时间更长的原因。
Background: The purpose of this study was to characterize an Australian cohort of ankylosing spondylitis (AS) patients and examine predictors of important disease outcomes.Methods: Cross-sectional study of first visit data among patients referred to the Austin Spondylitis Clinic from rheumatology or general practices. We obtained clinical and laboratory data and validated composite indices through self-reported questionnaire.Results: Delay in AS diagnosis averaged 8.1 years and was higher among women and younger-onset disease. Cervicothoracic mobility was better in women although they showed more entheseal tender points and greater impairment of quality of life. Those with long-standing AS had similar disease activity to recent onset disease but had greater functional disability. Current smoking was associated with worse outcomes although there was no association between cumulative exposure and AS outcomes.Conclusion: The clinical expression of AS in this first-described Australian cohort is similar to previously described cohorts. We observed greater cervicothoracic mobility and a higher enthesitis index among women perhaps contributing to longer delay to diagnosis.