Genetic linkage: interpreting lod scores.
Genetic linkage: interpreting lod scores.
复制标题
遗传连锁：解释 lod 分数。
DOI：
10.1126/science.1536004
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Risch,N
中科院分区：
文献类型：
--
作者：
Risch,N
先进的分子遗传学工具和与某些遗传性疾病如视网膜母细胞瘤、杜氏肌营养不良、囊性纤维化和神经纤维瘤病有关的基因的发现，引起了实验科学家和社会科学家对人类遗传学的兴趣。当一种遗传病的生化或生理基础未知时，如果要定位涉及的突变基因，就必须随机地对所有人类染色体进行连续搜索。
HE ADVENT OF SOPHISTICATED MOLECULAR GENETIC tools and discoveries of the genes identified with some inherited disorderssuch as retinoblastoma, Duchenne mus-cular dystrophy, cystic fibrosis, and neurofibromatosis have resulted in increased interest in human genetics by both experimental and social scientists. When the biochemical or physiologic basis for a genetic disease is unknown, a sequential search, at random, of all human chromosomesis necessary if the implicated mutant gene is to be located.