Chronic stress in caregivers of dementia patients is associated with reduced lymphocyte sensitivity to glucocorticoids
Chronic stress in caregivers of dementia patients is associated with reduced lymphocyte sensitivity to glucocorticoids
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DOI：
10.1016/s0165-5728(99)00228-3
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发表时间：
2000-02-01
影响因子：
3.3
通讯作者：
Shanks, N
中科院分区：
文献类型：
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作者：
Bauer, ME;Vedhara, K;Shanks, N
照顾慢性病患者与慢性痛苦有关。鉴于痛苦对细胞免疫功能的不利影响，这种痛苦可能会对健康产生影响。事实上，已经提出下丘脑-垂体-肾上腺（HPA）轴是这些效应的潜在心理生物学介质。在这项研究中，我们观察到，老年照顾者经历了更大的痛苦和增加唾液皮质醇比非照顾者。此外，看护者减弱了丝裂原诱导的淋巴细胞增殖，降低了丝裂原诱导的IL-2产生，并降低了淋巴细胞对糖皮质激素的敏感性。这些结果表明，慢性痛苦与受损的细胞介导的免疫力，这是，反过来，与升高的基础类固醇水平和改变类固醇免疫调节的淋巴细胞的水平。(C)2000由Elsevier Science B. V.出版，保留所有权利。
Caring for the chronically ill is associated with chronic distress. In view of the adverse effects of distress on cellular immune function, such distress may have implications for health. Indeed, it has been proposed that the hypothalamic-pituitary-adrenal (HPA) axis is a potential psychobiological mediator of these effects. In this study, we observed that elderly caregivers experienced greater distress and increased salivary cortisol than non-caregivers. In addition, caregivers had blunted mitogen-induced lymphocyte proliferation, lower mitogen-induced IL-2 production, and reduced lymphocyte sensitivity to glucocorticoids. These results indicate that chronic distress is associated with impaired cell-mediated immunity which is, in turn, associated with elevated basal steroid levels and altered steroid immunoregulation at the level of the lymphocyte. (C) 2000 Published by Elsevier Science B.V. All rights reserved.