Long-term outcome of autoimmune pancreatitis
Long-term outcome of autoimmune pancreatitis
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DOI：
10.1007/s00535-009-0049-3
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发表时间：
2009-07-01
影响因子：
6.3
通讯作者：
Okazaki, Kazuichi
中科院分区：
文献类型：
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作者：
Uchida, Kazushige;Yazumi, Shujiro;Okazaki, Kazuichi
目的自身免疫性胰腺炎（AIP）是一种独特的胰腺炎，可并发各种胰腺外病变。对AIP的长期临床病程知之甚少。在这里，我们旨在记录AIP的临床过程。方法在本研究中，我们招募了21例患者，平均年龄66.5岁（范围19-84岁），平均随访时间40.8个月（范围18130个月）。其中3例还被诊断为腹膜后纤维化，3例患有涎腺炎，2例患有慢性甲状腺炎，1例患有间质性肾炎，1例患有间质性肺炎。3例患者接受手术治疗，12例患者接受甲基强的松龙（PSL）治疗，6例患者未接受治疗。结果所有psl治疗的患者胰腺肿大均减轻。21例患者中有7例出现胰腺萎缩，其中2例未接受psl治疗。3例患者发展为慢性胰腺炎。一名患者在接受PSL治疗50个月后被诊断为胰腺癌。结论与慢性胰腺炎患者一样，应密切观察AIP患者胰腺功能的异常。
Purpose Autoimmune pancreatitis (AIP) is a unique form of pancreatitis and can be complicated with various extrapancreatic lesions. Little is known about the long-term clinical course of AIP. Here we aimed to document the clinical course of AIP.Methods For this study, we recruited 21 patients, averaging 66.5 years in age (range, 19-84 years) and observed them at a mean interval of 40.8 months (range, 18130 months). Three of the patients were also diagnosed with retroperitoneal fibrosis, 3 had sialoadenitis, 2 had chronic thyroiditis, 1 had interstitial nephritis, and 1 had interstitial pneumonia. Three of the patients underwent surgical therapy, 12 patients received methylprednisolone (PSL) treatment, and the 6 remaining patients received no treatment.Results Enlargement of the pancreas was attenuated in all the PSL-treated patients. Seven of the 21 patients showed pancreatic atrophy, of whom 2 were non-PSL-treated patients. Three patients developed chronic pancreatitis. One patient was diagnosed with pancreatic cancer after 50 months of PSL therapy.Conclusions As with chronic pancreatitis patients, AIP patients should be observed closely for abnormality in pancreatic function.