Role of CD36 in membrane transport of long-chain fatty acids
Role of CD36 in membrane transport of long-chain fatty acids
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DOI：
10.1097/00075197-200203000-00004
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发表时间：
2002-03-01
影响因子：
3.1
通讯作者：
Abumrad, NA
中科院分区：
文献类型：
--
作者：
Ibrahimi, A;Abumrad, NA
CD36是一种多特异膜糖蛋白，被认为具有多种功能。在分离的细胞以及小鼠和大鼠模型中产生的CD36表达改变的证据表明，CD36在长链脂肪酸的膜运输中发挥着重要作用。累积数据表明，CD36促进肌肉和脂肪摄取大部分脂肪酸，CD36缺乏与这些组织摄取脂肪酸的大缺陷(60%-80%)有关。在人类中，CD36基因的多态可能是脂肪酸代谢缺陷和某些形式的心脏病的基础。本文就目前对CD36转运功能及其调控的研究进展作一综述。运输步速限制了细胞对脂肪酸的利用，这一认识表明CD36表达或功能的异常可能会影响某些代谢性疾病的易感性，如肥胖和胰岛素抵抗。(C)2002年，里平科特·威廉姆斯·威尔金斯。
CD36 is a multispecific membrane glycoprotein that has been postulated to have a variety of functions. Evidence generated in isolated cells and in mice and rat models of altered CD36 expression has indicated an important role for CD36 in membrane transport of long-chain fatty acids. The cumulative data indicate that CD36 facilitates a major fraction of fatty acid uptake by muscle and fat, and that CD36 deficiency is associated with a large (60-80%) defect in fatty acid uptake by those tissues. In humans, polymorphisms in the CD36 gene may underlie defective fatty acid metabolism and some forms of heart disease. Herein we review our current understanding of the transport function and regulation of CD36. The realization that the transport step rate limits cellular fatty acid utilization suggests that abnormalities in CD36 expression or function may impact on susceptibility to certain metabolic diseases such as obesity and insulin resistance. (C) 2002 Lippincott Williams Wllkins.