Host Organelle Hijackers: a similar modus operandi for Toxoplasma gondii and Chlamydia trachomatis: co-infection model as a tool to investigate pathogenesis.
Host Organelle Hijackers: a similar modus operandi for Toxoplasma gondii and Chlamydia trachomatis: co-infection model as a tool to investigate pathogenesis.
复制标题
宿主细胞器劫持者：弓形虫和沙眼衣原体的类似作案方式：共同感染模型作为研究发病机制的工具。
DOI：
10.1111/2049-632x.12057
复制
发表时间：
2013-11
影响因子：
3.3
通讯作者：
Coppens I
中科院分区：
文献类型：
--
作者：
Romano JD;Coppens I
沙眼衣原体和弓形虫原虫分别是人类衣原体病和弓形虫病的病原体。这两种微生物都是专性的细胞内病原体，并因广泛改变其宿主细胞的细胞骨架结构和内膜系统而臭名昭著，以建立生产性感染。这篇综述强调了这两种病原体开发的相似策略来操纵它们的宿主细胞，尽管它们在基因上是不相关的。通过使用体外细胞培养模型，单个成纤维细胞同时感染沙眼衣原体和弓形虫，从而建立细胞内竞争，我们证明了寄生虫和细菌部署的细胞内生存问题的解决方案可能代表了收敛进化的例子，受在恶劣环境中获取营养的必要性的驱动。
The bacterium Chlamydia trachomatis and the protozoan parasite Toxoplasma gondii are the causative agents of chlamydiosis and toxoplasmosis in humans, respectively. Both micro-organisms are obligate intracellular pathogens and notorious for extensively modifying the cytoskeletal architecture and the endomembrane system of their host cells to establish productive infections. This review highlights the similar tactics developed by these two pathogens to manipulate their host cell despite their genetic unrelatedness. By using an in vitro cell culture model whereby single fibroblasts are infected by C. trachomatis and T. gondii simultaneously, thus setting up an intracellular competition, we demonstrate that the solutions to the problem of intracellular survival deployed by the parasite and the bacterium may represent an example of convergent evolution, driven by the necessity to acquire nutrients in a hostile environment.