Automated deformation analysis in the YAC128 Huntington disease mouse model
Automated deformation analysis in the YAC128 Huntington disease mouse model
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DOI：
10.1016/j.neuroimage.2007.08.033
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发表时间：
2008-01-01
期刊：
影响因子：
5.7
通讯作者：
Henkelman, R. Mark
中科院分区：
文献类型：
--
作者：
Lerch, Jason P.;Carroll, Jeffrey B.;Henkelman, R. Mark
YAC 128小鼠重现了亨廷顿病（HD）的许多临床特征，包括具有神经元损失的选择性神经病理学。在这里，我们调查是否可以使用高分辨率磁共振（MR）成像检测到神经解剖学的差异早于先前定义的9个月的纹状体神经病理学发病年龄。纹状体体积显著减小（3.4%，P
The YAC128 mouse recapitulates many of the clinical features of Huntington disease (HD), including selective neuropathology with neuronal loss. Here we investigate whether differences in neuroanatomy could be detected using high-resolution magnetic resonance (MR) imaging earlier than the previously defined 9-month age of onset of striatal neuropathology. The striatum is significantly decreased in volume (3.4%, p