Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94.
Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94.
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DOI：
10.1016/j.apsb.2014.11.001
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Guo Y
中科院分区：
文献类型：
--
作者：
Zhou Z;Wang X;Zhang H;Sun J;Zheng L;Liu H;Wang J;Shen A;Geng M;Guo Y
从深海来源的细菌色杆菌HS-13-94中分离出一种双环缩酚肽，即色肽A（1）。通过广泛的光谱分析和与相关已知化合物的比较确定了其结构。通过X射线衍射分析，采用石墨单色化Mo Kα辐射（λ=0.71073 λ）和小Flack参数0.03，确定了色肽A的绝对构型。结果显示，色肽A对HL-60、K-562和拉莫斯细胞的增殖均有抑制作用，其平均IC 50值分别为7.7、7.0和16.5 nmol/L。从深海来源的细菌色杆菌HS-13-94中分离出一种双环缩酚肽，即色肽A。确定了其结构。结果显示，色肽A对HL-60、K-562和拉莫斯细胞的增殖均有抑制作用，其IC_（50）值分别为7.7、7.0和16.5 nmol/L。
A bicyclic depsipeptide, chromopeptide A (1), was isolated from a deep-sea-derived bacterium Chromobacterium sp. HS-13-94. Its structure was determined by extensive spectroscopic analysis and by comparison with a related known compound. The absolute configuration of chromopeptide A was established by X-ray diffraction analysis employing graphite monochromated Mo Kα radiation (λ=0.71073 Å) with small Flack parameter 0.03. Chromopeptide A suppressed the proliferation of HL-60, K-562, and Ramos cells with average IC50 values of 7.7, 7.0, and 16.5 nmol/L, respectively. A bicyclic depsipeptide, chromopeptide A, was isolated from a deep-sea-derived bacterium Chromobacterium sp. HS-13-94. Its structure was determined. Chromopeptide A suppressed the proliferation of HL-60, K-562, and Ramos cells with average IC50 values of 7.7, 7.0 and 16.5 nmol/L, respectively.