COMPARISONS BETWEEN A NEW DRUG AND ACTIVE AND PLACEBO CONTROLS IN AN EFFICACY CLINICAL-TRIAL
COMPARISONS BETWEEN A NEW DRUG AND ACTIVE AND PLACEBO CONTROLS IN AN EFFICACY CLINICAL-TRIAL
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DOI：
10.1002/sim.4780110807
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发表时间：
1992-06-15
影响因子：
2
通讯作者：
TAMHANE, AC
中科院分区：
文献类型：
--
作者：
DUNNETT, CW;TAMHANE, AC
D'Agostino和Heeren （DH）讨论了在评估非处方药试验的敏感性和有效性时出现的多个比较问题。我们提出了灵敏度的一般定义，其中包括DH的定义作为一个特例。我们还提出了一种敏感性测试，它与Laska和Meisner的MIN测试在一个极端上是一致的，但它具有识别满足敏感性标准的特定药物的优势，当一些药物不能满足敏感性标准时。我们建议Dunnett测试及其扩展可能对疗效比较有用。
D'Agostino and Heeren (DH) discussed the multiple comparison issues that arise in evaluating both sensitivity and efficacy in over-the-counter drug trials. We propose a general definition of sensitivity that includes DH's definition as a special case. We also propose a test for sensitivity that coincides with the MIN test of Laska and Meisner at one extreme but has the advantage of identifying specific drugs satisfying the sensitivity criterion when some fail to do so. We suggest that the test of Dunnett as well as an extension of it may be useful for the efficacy comparisons.