Restoration of spinal bone in osteoporotic men by treatment with human parathyroid hormone (1–34) and 1,25‐dihydroxyvitamin D
Restoration of spinal bone in osteoporotic men by treatment with human parathyroid hormone (1–34) and 1,25‐dihydroxyvitamin D
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使用人甲状旁腺激素 (1-34) 和 1,25-二羟基维生素 D 治疗可恢复骨质疏松男性的脊柱骨
DOI：
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发表时间：
1986
影响因子：
6.2
通讯作者：
R. Neer
中科院分区：
文献类型：
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作者：
D. Slovik;D. Rosenthal;S. Doppelt;J. Potts;M. Daly;Julie A. Campbell;R. Neer
每日皮下注射合成人甲状旁腺激素片段，结合每日摄入1,25(OH)2维生素D，可显著增加特发性骨质疏松症中年男性脊柱小梁骨密度（p < 0.01），改善肠道钙磷吸收和膳食钙磷的全身潴留量。在一年的治疗中，脊柱骨矿物质的增加是显著的和进行性的。这些结果表明，增加膳食钙的肠道吸收，同时用小剂量甲状旁腺激素刺激新骨的形成，可以恢复骨质疏松症男性的脊柱骨。
Daily subcutaneous injection of a synthetic human parathyroid hormone fragment, combined with daily ingestion of 1,25(OH)2 vitamin D, significantly increased trabecular bone density in the spine (p < .01), and improved intestinal calcium and phosphorus absorption and total body retention of dietary calcium and phosphorus in middle‐aged men with idiopathic osteoporosis. The increases in spinal bone mineral were marked and progressive during a year of treatment. These results indicate that increasing intestinal absorption of dietary calcium while simultaneously stimulating new bone formation with small doses of parathyroid hormone can restore spinal bone in osteoporotic men.