Syntheses of sphingosine-1-phosphate stereoisomers and analogues and their interaction with EDG receptors.
Syntheses of sphingosine-1-phosphate stereoisomers and analogues and their interaction with EDG receptors.
复制标题
1-磷酸鞘氨醇立体异构体和类似物的合成及其与 EDG 受体的相互作用。
DOI：
10.1016/s0960-894x(02)00893-4
复制
发表时间：
2003
影响因子：
2.7
通讯作者：
Sung‐Kee Chung
中科院分区：
文献类型：
--
作者：
Hyun;Y. Oh;P. Suh;Sung‐Kee Chung
鞘氨醇-1-磷酸（S1 P）被认为是多种生物过程的重要调节剂，作为EDG受体的天然配体。作为开发EDG受体有效和选择性激动剂和拮抗剂的初步研究，我们报道了S1 P立体异构体和类似物的合成及其与EDG-1，-3和-5的结合亲和力。
Sphingosine-1-phosphate (S1P) is considered to be an important regulator of diverse biological processes acting as a natural ligand to EDG receptors. As a preliminary study to develop potent and selective agonist and antagonist for EDG receptors, we report synthesis of S1P stereoisomers and analogues and their binding affinities to EDG-1, -3, and -5.
影响因子：
56.9
作者：
Lee, MJ;Van Brocklyn, JR;Hla, T
通讯作者：
Hla, T