EVIDENCE OF PRENATAL INFLUENCES ON BREAST-CANCER RISK
EVIDENCE OF PRENATAL INFLUENCES ON BREAST-CANCER RISK
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DOI：
10.1016/0140-6736(92)93019-j
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发表时间：
1992-10-24
期刊：
影响因子：
168.9
通讯作者：
LAN, SJ
中科院分区：
文献类型：
--
作者：
EKBOM, A;TRICHOPOULOS, D;LAN, SJ
子宫内暴露于高浓度的内源性妊娠雌激素可能在乳腺癌的病因学中很重要。在一项巢式病例对照研究中，我们评估了乳腺癌风险与妊娠雌激素浓度指标之间的关系；先兆子痫/子痫呈负相关，胎儿大小的测量与雌激素浓度呈正相关。 1874 年至 1954 年间出生于乌普萨拉大学医院的女性的标准记录与浸润性乳腺癌病例记录相关，通过 1958-90 年间在瑞典癌症登记处的唯一国家登记号来识别。对于每个乳腺癌病例，我们选择了该病例母亲之后入院的前三位母亲的女性后代作为潜在对照；最终仅纳入了仍居住在瑞典且在诊断时未患乳腺癌的对照组。对 458 例乳腺癌病例和 1197 例匹配对照进行条件逻辑回归分析。先兆子痫/子痫与乳腺癌发病率之比为 0.24（95% 置信区间 0.09-0.70，p = 0.01）。乳腺癌发病率随出生体重、出生身长和胎盘重量的增加呈正线性趋势，但不显着。因此，产前因素在乳腺癌发生中很重要。妊娠期雌激素的浓度可能是此类因素之一，但不能排除其他产前或围产期因素。
Intrauterine exposure to high concentrations of endogenous pregnancy oestrogens may be important in the aetiology of breast cancer. In a nested case-control study we have assessed the relation between breast cancer risk and indicators of pregnancy oestrogen concentrations; preeclampsia/eclampsia is negatively related and measures of fetal size are positively related to oestrogen concentrations.Standard records for women born at Uppsala University Hospital between 1874 and 1954 were linked with records of invasive breast cancer cases, identified through their unique national registration numbers in the Swedish Cancer Registry during 1958-90. For each breast cancer case, we selected as potential controls female offspring of the first three mothers admitted to the hospital after the case's mother; only controls still living in Sweden and free from breast cancer when it was diagnosed in the case were finally included. Conditional logistic regression analysis was done for 458 breast cancer cases and 1197 matched controls. Pre-eclampsia/eclampsia was associated with a breast cancer rate ratio of 0.24 (95% confidence interval 0.09-0.70, p = 0.01). Linear trends for breast cancer incidence with increasing birth weight, birth length, and placental weight were positive but not significant.Thus, prenatal factors are important in breast carcinogenesis. Concentrations of pregnancy oestrogens may be one such factor, but other prenatal or perinatal factors cannot be excluded.