In Praise of Descriptive Science: A Breath of Fresh AIRE.
In Praise of Descriptive Science: A Breath of Fresh AIRE.
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DOI：
10.1016/j.cell.2016.07.018
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发表时间：
2016-07-28
期刊：
影响因子：
64.5
通讯作者：
Davis MM
中科院分区：
文献类型：
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作者：
Davis MM
Meyer等人发现，缺乏AIRE基因（对T淋巴细胞自身耐受至关重要）的受试者表现出广泛的自身抗体特异性，这些特异性可能具有极高的亲和力。数据还表明，令人惊讶的是，其中一些自身抗体可以预防某些类型的自身免疫，特别是I型糖尿病。
Meyer et al. find that subjects lacking the AIRE gene, critical for self-tolerance in T lymphocytes, show a broad range of autoantibody specificities, which can have extremely high affinities. The data also suggest that some of these autoantibodies can, surprisingly, prevent some types of auto-immunity, particularly type I diabetes.