Depression, rumination and the default network
Depression, rumination and the default network
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DOI：
10.1093/scan/nsq080
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发表时间：
2011-10-01
影响因子：
4.2
通讯作者：
Jonides, John
中科院分区：
文献类型：
--
作者：
Berman, Marc G.;Peltier, Scott;Jonides, John
严重抑郁障碍(MDD)的特征是过度的默认网络激活和与亚膝扣带回的连接。这些超连接通常被解释为反映了沉思，在这种情况下，MDDS坚持消极的、自我参照的想法。然而，连接和沉思之间的关系还没有建立起来。此外，以前的研究还没有研究个体在是否参与任务时与亚膝扣带回的连接性有何不同。本研究的目的是考察任务中和任务外的亚扣带回内缺省网络的连通性，以及连通性和冥想之间的关系。使用基于种子的连接性方法进行的分析表明，在休息期间，MDDS显示出比健康人更多的后扣带皮质和亚膝扣带皮质之间的神经功能连接，但在任务投入期间则不显示。重要的是，这些休息期的连通性与沉思和沉思的行为指标相关，但与反思无关。
Major depressive disorder (MDD) has been characterized by excessive default-network activation and connectivity with the subgenual cingulate. These hyper-connectivities are often interpreted as reflecting rumination, where MDDs perseverate on negative, self-referential thoughts. However, the relationship between connectivity and rumination has not been established. Furthermore, previous research has not examined how connectivity with the subgenual cingulate differs when individuals are engaged in a task or not. The purpose of the present study was to examine connectivity of the default network specifically in the subgenual cingulate both on- and off-task, and to examine the relationship between connectivity and rumination. Analyses using a seed-based connectivity approach revealed that MDDs show more neural functional connectivity between the posterior-cingulate cortex and the subgenual-cingulate cortex than healthy individuals during rest periods, but not during task engagement. Importantly, these rest-period connectivities correlated with behavioral measures of rumination and brooding, but not reflection.