The problem of bacillus species infection with special emphasis on the virulence of Bacillus cereus.
The problem of bacillus species infection with special emphasis on the virulence of Bacillus cereus.
复制标题
芽孢杆菌属感染问题特别强调蜡状芽孢杆菌的毒力。
DOI：
10.1016/s0161-6420(81)34960-4
复制
发表时间：
1981
期刊：
影响因子：
13.7
通讯作者：
Ho,PC
中科院分区：
文献类型：
--
作者：
O'Day,DM;Smith,RS;Gregg,CR;Turnbull,PC;Head,WS;Ives,JA;Ho,PC
虽然蜡样芽孢杆菌是一种不常见的眼部病原体，但感染它通常会导致眼睛丧失。尽管之前的报告强调了内源性感染，但我们最近的经验表明了创伤后蜡状芽胞杆菌感染的重要性。当前经验性抗生素治疗方案的无效性阻碍了治疗。该微生物对青霉素和头孢菌素均具有抗性。虽然蜡样芽胞杆菌对庆大霉素敏感，但我们的研究表明庆大霉素本身不足以根除感染。然而，蜡样芽胞杆菌对克林霉素敏感，庆大霉素和克林霉素联合治疗似乎提供了最佳方法。早期诊断是成功治疗的关键。我们认为，可能导致蜡样芽胞杆菌感染的临床情况以及疾病本身的表现都足够独特，足以提醒眼科医生注意这种感染的可能性。及时识别感染应允许在发生永久性结构变化之前采取适当的治疗。
AlthoughBacillus cereusis an uncommon ocular pathogen, infection with it usually results in loss of the eye. Although previous reports have emphasized endogenous infection, our recent experience indicates the importance ofB cereusinfection following trauma. Management is hampered by ineffectiveness of current empirical antibiotic regimens. This microorganism is resistant to both the penicillins and the cephalosporins. AlthoughB cereusis susceptible to gentamicin, our studies indicate that gentamicin by itself is inadequate to eradicate the infection.B cereus, however, is susceptible to clindamycin and combined therapy with gentamicin and clindamycin appears to offer the best approach. Early diagnosis is the key to successful treatment. We believe the clinical circumstances likely to lead toB cereusinfection, as well as the manifestations of the disease itself, are sufficiently distinctive to alert the ophthalmologist to the possibility of this infection. Prompt recognition of the infection should allow institution of appropriate therapy before permanent structural changes occur.