A review of photocrosslinked polyanhydrides: in situ forming degradable networks
A review of photocrosslinked polyanhydrides: in situ forming degradable networks
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DOI：
10.1016/s0142-9612(00)00107-1
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发表时间：
2000-12-01
期刊：
影响因子：
14
通讯作者：
Anseth, KS
中科院分区：
文献类型：
--
作者：
Burkoth, AK;Anseth, KS
许多骨科损伤可以受益于具有良好组织相容性的高强度和可降解材料。此外，临床上对外科医生容易勾勒出轮廓或放置到复杂形状缺陷中的材料有很大的需求。我们合理地设计了一类新型的光交联型聚酸酐单体，这些单体在原位形成了具有复杂几何结构的高强度和表面腐蚀网络。本文着重介绍了这些材料在骨科应用的优点，以及在生理条件下光聚合反应这些单体的技术。介绍了材料设计的基本原理、光聚合动力学、皮下组织中的降解行为和组织学以及一个骨缺损模型。(C)2000爱思唯尔科学有限公司。保留所有权利。
Many orthopaedic injuries could benefit from a high-strength and degradable material with good tissue compatibility. In addition, there is a great clinical need for materials which are easily contoured or placed into complex-shaped defects by a surgeon. We have rationally designed a new class of photocrosslinkable polyanhydride monomers which in situ form high-strength and surface eroding networks of complex geometries. This paper highlights the advantages of these materials for orthopaedic applications and the technique of photopolymerization for reacting these monomers under physiological conditions. The rationale for the material design, photopolymerization kinetics, degradation behavior, and histology in subcutaneous tissue and a model bone defect are presented. (C) 2000 Elsevier Science Ltd. All rights reserved.