Regression in malignant melanoma. A histologic feature without independent prognostic significance
Regression in malignant melanoma. A histologic feature without independent prognostic significance
复制标题
恶性黑色素瘤的消退。
作者：
J. Kelly;R. Sagebiel;M. S. Blois
总共对844例皮肤恶性黑色素瘤进行了前瞻性检查，以确定原发肿瘤内是否存在组织学退行性变化。然后根据肿瘤厚度将病例分成三组，并比较每组中有无消退的基底物之间的生存率。评估了其他主要预后变量在这些底物中的分布，并考虑了它们作为潜在混杂变量的影响。在三个厚度层中的任何一个中，均未发现回归对生存的显著影响。这些结果并不证实先前一项研究的发现，该研究表明，当发现与细小恶性黑色素瘤相关时，退化可能是一个不良的预后迹象。退化几乎总是与黑色素瘤的放射状增生期有关。男性患者的退行性病变比女性患者更常见，躯干黑色素瘤比四肢或头颈部黑色素瘤更常见。
A total of 844 cutaneous malignant melanomas were examined prospectively for the presence or absence of histologic regression within the primary tumor. Cases were then stratified into three groups according to tumor thickness and survival was compared between substrata with and without regression in each group. The distribution of other major prognostic variables within these substrata was assessed and their influence as potential confounding variables considered. No statistically significant effect of regression on survival was found in any of the three thickness strata. These results do not confirm the finding of an earlier study, which suggested that regression may be a poor prognostic sign when found in association with thin malignant melanomas. Regression was almost invariably associated with the radial growth phase of melanomas. Regression was more common in male than in female patients, and was more frequent in association with truncal than extremity or head and neck melanomas.