CA3 size predicts the precision of memory recall
CA3 size predicts the precision of memory recall
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DOI：
10.1073/pnas.1319641111
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发表时间：
2014-07-22
影响因子：
11.1
通讯作者：
Maguire, Eleanor A.
中科院分区：
文献类型：
--
作者：
Chadwick, Martin J.;Bonnici, Heidi M.;Maguire, Eleanor A.
鉴于检索能力和区分过去经历的精确度存在巨大的个体差异，为什么我们中的一些人比其他人拥有更清晰的记忆一直是人们感兴趣的问题。在这里，我们报告了新的证据，表明人类海马子区域 CA3 的大小变化预测了 CA3 内情景记忆之间的神经干扰量，这反过来又预测了过去记忆之间发生的检索混淆程度。这种效应在其他海马亚区中并不明显。这表明，主观记忆体验中细微的个体差异可以通过海马区 CA3 的解剖结构和神经编码的可测量变化来准确衡量。此外，这种机制可能与理解衰老和病理状态下的记忆混乱有关。
There is enduring interest in why some of us have clearer memories than others, given the substantial individual variation that exists in retrieval ability and the precision with which we can differentiate past experiences. Here we report novel evidence showing that variation in the size of human hippocampal subfield CA3 predicted the amount of neural interference between episodic memories within CA3, which in turn predicted how much retrieval confusion occurred between past memories. This effect was not apparent in other hippocampal subfields. This shows that subtle individual differences in subjective mnemonic experience can be accurately gauged from measurable variations in the anatomy and neural coding of hippocampal region CA3. Moreover, this mechanism may be relevant for understanding memory muddles in aging and pathological states.