Mechanisms of leukocyte migration across the blood-retina barrier.
Mechanisms of leukocyte migration across the blood-retina barrier.
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DOI：
10.1007/s00281-008-0106-7
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发表时间：
2008-04
影响因子：
9
通讯作者：
Liversidge, Janet
中科院分区：
文献类型：
--
作者：
Crane, Isabel J.;Liversidge, Janet
关键词：
视网膜中免疫介导的炎症由解剖学、生理学和免疫调节机制的组合调节，称为血视网膜屏障（BRB）。BRB被认为是专门的眼部微环境的一部分，通过偏离或抑制破坏性炎症来赋予保护或“免疫特权”。血液循环和视网膜之间的屏障维持在两个独立的解剖部位。这些是视网膜内血管系统的内皮细胞和在有窗孔的脉络膜血管和外部视网膜之间的布鲁赫膜上的视网膜色素上皮细胞。描述了形成物理屏障的紧密连接的结构和调节。为了使白细胞迁移穿过BRB，白细胞本身和形成屏障的细胞都需要发生变化。我们回顾了血视网膜屏障是如何在各种炎症性疾病中受损的，并更详细地讨论了葡萄膜视网膜炎中控制白细胞亚群迁移到视网膜的机制。特别是，我们研究了选择素和整合素在白细胞与血管内皮相互作用中的相对作用，以及趋化因子在白细胞亚群的选择性招募、触发粘附、渗出和炎性细胞迁移到视网膜组织中的关键作用。
Immune-mediated inflammation in the retina is regulated by a combination of anatomical, physiological and immuno-regulatory mechanisms, referred to as the blood–retina barrier (BRB). The BRB is thought to be part of the specialised ocular microenvironment that confers protection or “immune privilege” by deviating or suppressing destructive inflammation. The barrier between the blood circulation and the retina is maintained at two separate anatomical sites. These are the endothelial cells of the inner retinal vasculature and the retinal pigment epithelial cells on Bruch’s membrane between the fenestrated choroidal vessels and the outer retina. The structure and regulation of the tight junctions forming the physical barrier are described. For leukocyte migration across the BRB to occur, changes are needed in both the leukocytes themselves and the cells forming the barrier. We review how the blood–retina barrier is compromised in various inflammatory diseases and discuss the mechanisms controlling leukocyte subset migration into the retina in uveoretinitis in more detail. In particular, we examine the relative roles of selectins and integrins in leukocyte interactions with the vascular endothelium and the pivotal role of chemokines in selective recruitment of leukocyte subsets, triggering adhesion, diapedesis and migration of inflammatory cells into the retinal tissue.
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影响因子：
37.8
作者：
Combadière, C;Potteaux, S;Mallat, Z
通讯作者：
Mallat, Z
影响因子：
9.8
作者：
Chen, Jing;Smith, Lois E. H.
通讯作者：
Smith, Lois E. H.
影响因子：
3.1
作者：
Cai, J;Jiang, WG;Boulton, M
通讯作者：
Boulton, M
影响因子：
32.4
作者：
Bakker, ABH;Hoek, RM;Lanier, LL
通讯作者：
Lanier, LL
影响因子：
2
作者：
CASPI, RR;CHAN, CC;CHADER, GJ
通讯作者：
CHADER, GJ