Adolescent cannabinoid exposure permanently suppresses cortical oscillations in adult mice.
Adolescent cannabinoid exposure permanently suppresses cortical oscillations in adult mice.
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青少年接触大麻素会永久抑制成年小鼠的皮质振荡。
DOI：
10.1038/npp.2013.164
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Keller,Asaf
中科院分区：
文献类型：
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作者：
Raver,SylvinaM;Haughwout,SarahP;Keller,Asaf
在青春期而不是成年期经常使用大麻可能会永久性地损害认知能力，并增加精神疾病的风险，如精神分裂症。皮层振荡是认知过程的组成部分，在精神分裂症患者中是异常的。我们测试的假设，青春期是一个敏感的时期，因为积极发展的皮层振荡和神经调节系统，他们的基础。大麻作用的内源性大麻素系统就是这样一个系统。在这里，我们测试的预测，青少年大麻素暴露改变成年人的皮质振荡。使用体外局部场电位、体内皮质电图记录和成年小鼠的认知行为测试，我们证明青少年（而不是成年）大麻素暴露会抑制药理学诱发的皮质振荡并损害成年人的工作记忆表现。较晚成熟的前额叶皮层比较早成熟的初级躯体感觉皮层对青少年暴露更敏感。这些数据建立了慢性青少年大麻素暴露与成人皮质网络活动改变之间的联系，这些活动是认知过程的基础。
Regular marijuana use during adolescence, but not adulthood, may permanently impair cognition and increase the risk for psychiatric diseases, such as schizophrenia. Cortical oscillations are integral for cognitive processes and are abnormal in patients with schizophrenia. We test the hypothesis that adolescence is a sensitive period because of the active development of cortical oscillations and neuromodulatory systems that underlie them. The endocannabinoid system upon which marijuana acts is one such system. Here we test the prediction that adolescent cannabinoid exposure alters cortical oscillations in adults. Using in vitro local field potential, in vivo electrocorticogram recordings and cognitive behavioral testing in adult mice, we demonstrate that chronic adolescent, but not adult, cannabinoid exposure suppresses pharmacologically evoked cortical oscillations and impairs working memory performance in adults. The later-maturing prefrontal cortex is more sensitive to adolescent exposure than the earlier-maturing, primary somatosensory cortex. These data establish a link between chronic adolescent cannabinoid exposure and alterations in adult cortical network activity that underlie cognitive processes.