Benefits of pulmonary rehabilitation in COVID-19: a prospective observational cohort study
Benefits of pulmonary rehabilitation in COVID-19: a prospective observational cohort study
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DOI：
10.1183/23120541.00108-2021
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发表时间：
2021-04-01
影响因子：
4.6
通讯作者：
Koczulla, Andreas R.
中科院分区：
文献类型：
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作者：
Gloeckl, Rainer;Leitl, Daniela;Koczulla, Andreas R.
背景资料：2019冠状病毒病（COVID-19）可导致各种慢性健康问题，如肺功能受损、运动表现下降和生活质量下降。我们的研究旨在调查COVID-19患者肺康复的有效性、可行性和安全性，并比较轻/中度和重度/危重病程患者的结局。方法：这项前瞻性、观察性队列研究纳入了接受为期3周的综合住院肺康复计划的轻度至危重COVID-19急性期后患者。在肺康复治疗前后评估了运动能力（6分钟步行距离（6 MWD））、肺功能（用力肺活量（FVC））和生活质量（36个问题的简明健康调查表（SF-36））的几项指标。结果：50例患者入选研究（24例轻度/中度和26例重度/危重COVID-19）。入院时，患者的6 MWD降低（轻度：中位数509 m，四分位距（IQR）426-539 m;重度：344 m，244-392 m），FVC受损（轻度：80%，59-91%;重度：75%，60-91%）和低SF-36心理健康评分（轻度：49分，37-54分;重度：39分，30-53分）。患者参加了所有提供的肺康复疗程的中位数（IQR）100%（94-100%）。出院时，两个亚组患者的6 MWD均有所改善（轻度/中度：+48 m，35-113 m;重度/危重：+124 m，75-145 m;两个亚组均为P
Background: Coronavirus disease 2019 (COVID-19) can result in a large variety of chronic health issues such as impaired lung function, reduced exercise performance and diminished quality of life. Our study aimed to investigate the efficacy, feasibility and safety of pulmonary rehabilitation in COVID-19 patients and to compare outcomes between patients with a mild/moderate and a severe/critical course of the disease.Methods: Patients in the post-acute phase of a mild to critical course of COVID-19 admitted to a comprehensive 3-week inpatient pulmonary rehabilitation programme were included in this prospective, observational cohort study. Several measures of exercise performance (6-min walk distance (6MWD)), lung function (forced vital capacity (FVC)) and quality of life (36-question short-form health survey (SF-36)) were assessed before and after pulmonary rehabilitation.Results: 50 patients were included in the study (24 with mild/moderate and 26 with severe/critical COVID-19). On admission, patients had a reduced 6MWD (mild: median 509 m, interquartile range (IQR) 426-539 m; severe: 344 m, 244-392 m), an impaired FVC (mild: 80%, 59-91%; severe: 75%, 60-91%) and a low SF-36 mental health score (mild: 49 points, 37-54 points; severe: 39 points, 30-53 points). Patients attended a median (IQR) 100% (94-100%) of all provided pulmonary rehabilitation sessions. At discharge, patients in both subgroups improved in 6MWD (mild/moderate: +48 m, 35-113 m; severe/critical: +124 m, 75-145 m; both p