DIFFERENTIATION BETWEEN DYSMYELINATION AND DEMYELINATION USING MAGNETIC-RESONANCE DIFFUSIONAL ANISOTROPY
DIFFERENTIATION BETWEEN DYSMYELINATION AND DEMYELINATION USING MAGNETIC-RESONANCE DIFFUSIONAL ANISOTROPY
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DOI：
10.1016/0006-8993(94)01335-f
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发表时间：
1995-02-06
期刊：
影响因子：
2.9
通讯作者：
OKADA, S
中科院分区：
文献类型：
--
作者：
ONO, J;HARADA, K;OKADA, S
应用磁共振弥散加权方法，分别对Pelizaeus-Merzbacher病和Krabbe病脱髓鞘障碍的动物模型小鼠和抽动小鼠的视神经和三叉神经进行了检查。在娇小的小鼠中，视神经的扩散各向异性与年龄匹配的对照组小鼠没有显著差异，这表明在缺乏多层髓鞘的情况下确实存在扩散各向异性。在Twitcher小鼠中，视神经和三叉神经的弥散各向异性显著减弱。经电子显微镜证实的轴突纵切面直线度的丧失似乎是其主要原因。这进一步表明，这种磁共振弥散加权成像方法使我们能够在活体内区分髓鞘减少症和脱髓鞘病。
Using magnetic resonance (MR) diffusion-weighted method, we examined the optic and the trigeminal nerves of jimpy and twitcher mice, considered to be animal models of Pelizaeus-Merzbacher disease, hypomyelination disorder, and Krabbe disease, demyelination disorder, respectively. In jimpy mice, diffusional anisotropy of optic nerve did not show a significant difference compared to age-matched control mice, suggesting that diffusional anisotropy does exist in absence of multiple layers of myelin sheath. In twitcher mice, diffusional anisotropy was attenuated remarkably in the optic and trigeminal nerves. Loss of axonal straightness on longitudinal section confirmed by electron microscopy appeared to be the principal explanation for it. It is further suggested that this MR diffusion-weighted imaging method enables us to differentiate hypomyelination from demyelination in vivo.