Population-based survival for childhood cancer patients diagnosed during 2002-2005 in Shanghai, China
Population-based survival for childhood cancer patients diagnosed during 2002-2005 in Shanghai, China
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DOI：
10.1002/pbc.24043
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发表时间：
2012-10-01
影响因子：
3.2
通讯作者：
Fan, Wu
中科院分区：
文献类型：
--
作者：
Bao, Ping-ping;Zheng, Ying;Fan, Wu
背景：目前中国还没有基于人群的014岁儿童癌症生存研究。在本研究中，我们旨在描述上海儿童癌症的生存特征。本研究纳入2002年至2005年期间在上海癌症登记处登记并参加上海儿童生存研究的儿童癌症病例。我们使用KaplanMeier产品限制法进行生存分析，并使用Cox比例风险模型调查各种预后因素的影响。结果中位随访时间为5.4年（范围为08.9年）。所有儿童癌症的5年观察生存率为55.7% （95% CI: 51.759.6%）。对于白血病、淋巴瘤和中枢神经系统肿瘤这三种最常见的儿童癌症，5年生存率分别为52.2%、58.8%和41.2%。上皮癌（88.9%）、恶性肾肿瘤（86.7%）、生殖细胞及其他性腺肿瘤（78.4%）和视网膜母细胞瘤（75.0%）的5年生存率较高。预后不良的肿瘤包括交感神经系统肿瘤（57.9%）、软组织肉瘤（54.1%）、骨肿瘤（52.6%）和肝癌（33.3%）。生存率在性别和年龄组之间没有显著差异。与美国和欧洲的报告相比，上海所有癌症和三种最常见类型的生存率都较低。结论2002 - 2005年上海市014岁儿童肿瘤生存率处于中等水平。在上海和特定的发达国家，儿童癌症的存活率有很大的差异。儿科血癌2012；59:65 - 76。(c) 2012 Wiley期刊有限公司
Background There have been no population-based studies on cancer survival among children aged 014 years in China. In this study, we aimed to characterize the cancer survival among children in Shanghai. Procedure Childhood cancer cases registered by the Shanghai Cancer Registry between 2002 and 2005 and enrolled in the Shanghai Childhood Survival Study were included in this study. We used KaplanMeier product-limit method for survival analysis and Cox proportional hazards models for investigating the effects of various prognostic factors. Results The median follow-up time was 5.4 years (range 08.9 years). The 5-year observed survival for all childhood cancers combined was 55.7% (95% CI: 51.759.6%). For leukemia, lymphoma, and central nervous system tumors, the three most common types of childhood cancer, 5-year survival rates were 52.2%, 58.8%, and 41.2%, respectively. Higher 5-year survival rates were observed for epithelial cancer (88.9%), malignant renal tumors (86.7%), germ cell and other gonadal tumors (78.4%), and retinoblastoma (75.0%). Cancers with poor prognosis included sympathetic nervous system tumors (57.9%), soft tissue sarcoma (54.1%), bone tumors (52.6%), and liver cancer (33.3%). There were no significant differences between survival rates by gender and age groups. Compared with those reported in the USA and Europe, the survival rates for all cancers combined and the three most common types in Shanghai were lower. Conclusions The survival rate for children aged 014 diagnosed with cancer in Shanghai during 20022005 was at the medium level. There was a substantial survival difference from childhood cancers between Shanghai and specific developed countries. Pediatr Blood Cancer 2012;59:657661. (c) 2012 Wiley Periodicals, Inc.