Altered serotonin 2C receptor RNA splicing in suicide: association with editing
Altered serotonin 2C receptor RNA splicing in suicide: association with editing
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DOI：
10.1097/wnr.0b013e3282f556d2
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发表时间：
2008-02-12
期刊：
影响因子：
1.7
通讯作者：
Haroutunian, Vahram
中科院分区：
文献类型：
--
作者：
Dracheva, Stella;Chin, Benjamin;Haroutunian, Vahram
在早期的一项研究中，我们发现前额叶皮层中5-羟色胺2C受体（5-HT 2CR）前mRNA编辑的增加是自杀受害者特有的，而与相关的精神病诊断无关。在这里，我们证明了两个5-HT 2CR剪接变异体之间的比例在自杀的人中增加，但在诊断组之间没有变化。这为自杀特异性神经生物学提供了进一步的证据，并表明，正如之前在体外所显示的那样，5-HT 2CR编辑调节其在人脑中的剪接。然而，关联分析表明，5-HT 2CR编辑的效率是一个不完美的预测剪接的结果，剪接位点的选择，只有部分控制的编辑水平在体内。
In an earlier study, we showed increases in serotonin 2C receptor (5-HT2CR) pre-mRNA editing in prefrontal cortex that were specific to suicide victims irrespective of associated psychiatric diagnoses. Here we demonstrate that the ratio between the two 5-HT2CR splice variants is increased in people who committed suicide, but does not vary among the diagnostic groups. This provides further evidence for suicide-specific neurobiology and suggests that, as it was previously shown in vitro, 5-HT2CR editing modulates its splicing in human brain. The association analysis indicates, however, that the efficiency of 5-HT2CR editing is an imperfect predictor of the splicing outcome, and that splice site selection is only partially controlled by the level of editing in vivo.